Publications

💡 About the Article:

Alzheimer’s Disease (AD) is a complex neurodegenerative disorder with no known cure. This comprehensive review presents a holistic, multi-pronged strategy that goes beyond conventional treatments—integrating cutting-edge approaches from regenerative medicine, cellular therapy, and personalized lifestyle interventions.

📌 Key Highlights:

✔️ The article explores the roles of neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic failure in AD pathology
✔️ It introduces the potential of peptide therapy, nano-organo preparations, and cell therapy to modulate neurodegeneration and promote neuroregeneration
✔️ Emphasis on the gut-brain axis, blood-brain barrier integrity, and immune modulation as therapeutic targets
✔️ Advocates for an integrative care model—blending science-based interventions with functional, metabolic, and lifestyle medicine for optimal brain health and quality of life

🔬 This paper charts a forward-looking path for managing AD with precision tools that address root causes—not just symptoms—of cognitive decline.

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💡 About the Publication:

This powerful review explores how mesenchymal stem cells (MSCs) and neural stem/progenitor cells (NSPCs) offer transformative potential in the treatment of complex neurodegenerative and neuroinflammatory diseases such as Alzheimer’s, Parkinson’s, ALS, MS, stroke, TBI, and SCI.

These two stem cell types are uniquely positioned to:

✔️ Address key pathologies like neuronal loss, inflammation, and blood-brain barrier (BBB) dysfunction
✔️ Promote cell replacement, neuroprotection, synaptic plasticity, and remyelination
✔️ Deliver therapeutic effects through direct regeneration and powerful paracrine signaling
✔️ Reduce oxidative stress and neuroinflammation, while enhancing recovery through trophic and immunomodulatory actions

With insights from clinical and preclinical models, the article also compares the unique advantages and limitations of MSCs and NSPCs and provides a roadmap for optimizing their clinical translation

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Unlock the future of healing with Compendium of Diseases and Disorders: Clinical Applications of Stem Cells with Precision in Regenerative Medicine. Authored by pioneering scientist Prof. Dr. Mike Chan, this groundbreaking volume bridges cutting-edge research and real-world clinical application. It explores how targeted progenitor and precursor stem cells can transform the treatment of a wide range of diseases—from neurodegenerative conditions and cardiovascular disorders to aging-related syndromes and immune deficiencies. Designed for healthcare professionals, researchers, and innovators, this compendium offers a visionary yet practical guide to the evolving frontiers of regenerative medicine, emphasizing precision, ethical responsibility, and hope for conditions once deemed untreatable.

Prof. Dr. Mike K.S. Chan is an author, educator, and pioneer in Cellular, Organo, and Cell Membrane Therapies in Europe and Asia since the early 1980s. He founded one of the world’s largest research groups in Bio-Molecular Medicine, headquartered in Switzerland and Germany, with a global presence in nearly eighty countries. He has delivered more than 1,000 lectures, seminars, and symposiums worldwide in the fields of anti-aging, cell regeneration, bio-regenerative medicine, and stem cell therapies.
He is the author or co-author of over 60 scientific and medical books covering stem cells, aging, neurodegenerative and neurodevelopmental disorders, metabolic diseases, and biological as well as regenerative medicine. Prof. Dr. Chan serves on the board and chairs the Scientific Committee for Regenerative Medicine at ESAAM. He is also an Associate Professor at AASCP, USA; an Adjunct Professor and Fellow of Lincoln University College, USA (Kuala Lumpur campus); Chairman of the Medical Association for Regenerative Medicine in Japan (MMJ – Multi-Dimensional Holistic Medical Team Japan); and a Senator of BWA, Germany (Federal Association for Economic Development and Foreign Trade), representing China, Indonesia, and Malaysia.
He has played a pivotal role in advancing medical and wellness tourism, as well as educational tourism, in Switzerland, Germany, and Malaysia collaborating with physicians from the USA, Portugal, Poland, Belgium, China, Spain, the UK, Indonesia, Taiwan, Australia, New Zealand, Thailand, Singapore, Vietnam, the Philippines, and the Middle East.

Prof. Dr. Michelle B.F. Wong is a distinguished scientist, researcher, and educator, actively engaged in stem cell research and development (R&D), with a particular focus on fetal precursor stem cell therapy. For over three decades, she has served as Co-Founder, Senior Technical Advisor, and Researcher at FCTI Inc., a company specializing in stem cell research and bio-regenerative medicine.Her solid academic foundation in nutrition and naturopathy has facilitated a seamless transition into R&D within the field of stem cell bioregenerative medicine.
Dr. Wong is also a highly respected speaker, regularly delivering presentations at educational programs and international conferences on topics such as stem cells, cell therapy, and biological medicine—benefiting physicians and healthcare practitioners worldwide.

In a groundbreaking study, researchers are now exploring the potential of using a patient’s own bone marrow-derived stem cells to provide stem cell therapy for managing diabetes – essentially harnessing the body’s own power! 💪

Here are some key insights…

✅ A Safer Approach: Could using a patient’s own bone marrow stem cells (autologous BMMNCs) offer a potentially safer route for diabetes therapy by minimizing risks seen with donor cells?

✅Potential for Better Control: Clinical studies suggest autologous BMMNC infusion holds promise for improving blood sugar levels (HbA1c) and possibly reducing insulin needs in Type 1 & Type 2 Diabetes.

✅ Hope for Patients with Complications: This therapy shows potential for addressing difficult diabetes-related issues e.g. conditions like kidney problems (nephropathy) or non-healing foot ulcers.

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Authors: Prof. Dr. Mike K.S. Chan and Dr. Alaa Abdelkairm Fouad
Publisher: Journal of Biology and Medical Research; 6(1), 2025
Publisher's URL: https://www.imedpub.com/articles/advancing-cellular-therapy-with-the-ace-pico-protocol-overcoming-multidosing-challenges-in-stem-cell-applications.php?aid=53481

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Our planet is getting older... Aging is a natural and inevitable process and part of our lives, but it increases the risk of numerous diseases, one of which is cardiovascular pathology. Despite the successful progress in modern medicine, cardiovascular diseases remain a leading cause of death worldwide. What makes age-related heart disease so difficult to combat? What eludes our understanding of the reasons for this? And why do existing treatments not meet expectations?

One of the root causes is a concealed factor: chronic low-grade inflammation that occurs even without any apparent infection or acute inflammatory stimulus and fuels the aging process within our cells. This phenomenon, known as “InflammAging”, accelerates heart aging and increases vulnerability to disease.

In this book, we tried to look at the problem of cardiac aging from the point of view of internal cellular mechanisms and uncover how innovative bioregenerative therapies can revolutionize the way we prevent and treat and open up new opportunities for extending cardiac longevity. By targeting InflammAging at its core, we aim to unlock a new path to long-term heart health and extended vitality.

Discover the future of heart health within these pages.

Stem cell therapy is taking a bold step forward – or rather, a leap inward! Researchers in a recent study have shifted focus from whole-cell treatments to cell-free approaches, like peptides and exosomes, that carry similarly potent regenerative potential…  but without the complexities of cell transplantation.

Here’s why this matters:

✅ Precision repair: Stem cell peptides like Nano Organo Peptides™ and Mito Organelles™ mimic natural cell signals, regenerating damaged tissues and boosting mitochondrial function.

✅ Safer innovation: Exosomes, tiny vesicles packed with bioactive molecules, deliver therapeutic benefits without the risks of tumorigenesis or immune rejection.

✅ Broad applications: From reversing heart damage to enhancing joint health and tackling diabetes, these tools are unlocking new, less invasive ways to heal.

Read more in the groundbreaking publication here:

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In a recent study, researchers tested “Mito Organelles™” cellular extracts on human cells exposed to oxidative stress – conditions that usually suppress cell vitality. Surprisingly, these extracts didn’t just protect the cells… they actually helped them thrive under pressure.

Even better? No signs of toxicity or cancerous changes were detected, suggesting these extracts might potentially offer a safe edge in cellular health.

Could this be a new frontier for boosting cell resilience without the risks? It’s early, but the potential is exciting!

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Authors: Jonathan R.T. Lakey, Michael Alexander, Prof. Dr. Mike K.S. Chan, Prof. Dr. Yuriy Nalapko, Prof. Dr. Michelle B.F. Wong and Desiree C.T. Cox
Publisher: International Journal of Translational Science; 2024(2), 2024
Publisher's URL: https://doi.org/10.13052/ijts2246-8765.2024.023

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Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Prof. Dr. Thomas Skutella, Dr. Roni Lara Moya and Dr. Dmytro Klokol
Publisher: Journal of Stem Cells Research Development & Therapy; 9:106, 2023
Publisher's URL: https://doi.org/10.24966/SRDT-2060/100106

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