Bietti’s Crystalline Dystrophy

This presentation provides a detailed overview of Bietti’s crystalline dystrophy, a rare autosomal recessive retinal disorder caused by mutations in the CYP4V2 gene. It explains how impaired fatty-acid metabolism contributes to crystalline deposits, retinal pigment epithelium dysfunction, photoreceptor degeneration, and progressive vision loss. The presentation covers epidemiology, clinical symptoms, diagnostic imaging, genetic testing, supportive management, and emerging gene-based research. A major section explores regenerative and biomolecular approaches, including precursor stem cell therapy, mitochondria-targeted peptides, nano organo peptides, and ocular peptide formulations intended to support retinal cells, cellular energy, optic nerve function, and tissue repair.