Publications

The success of transplantation to treat human diseases has greatly increased the demand for organs and tissues. Xenotransplantation, the use of animals as donors, is viewed increasingly as a solution to this problem. The pig-to-NHP model has become the standard for preclinical studies of cell and tissue xenotransplantation prior to starting a clinical trial.

This is A Compilation of Cell and Tissue Xenotransplantation Studies (1838-2022): A Promising Approach for the Treatment of Diseases and a collection of reminiscences by surgeons and scientists who made significant research contributions toward achieving successful transplantation of animal cells and tissues into humans. It records the works of the world’s leading researchers in this field which will impact the future medical care of patients with diabetes, liver failure, neurodegenerative disorders, corneal blindness, etc.

It also provides a comprehensive overview of applications of cellular and tissue xenotransplantation for a range of diseases especially those that result from tissue loss or dysfunction. The importance of the decellularization technique in animal tissues and organs as implantable biomaterials in the field of regenerative medicine and tissue engineering is also highlighted.

Essential reading for physicians, scientists, and lay persons with an interest in xenotransplantation; those caring for patients with life-threatening diseases; and also those interested in understanding the potential of genetic and tissue engineering in science and medicine. This book charts a historical record of the research which has contributed to the advancement of medicine called “the next great medical revolution.” Many believe we are on the threshold of clinical trials using genetically modified animals as organ donors. If successful, the benefits of clinical xenotransplantation will be enormous and will represent one of the greatest advances in modern medicine.

This handbook focuses on the different aspects around the anti-aging, preventive and regenerative medicine. Discussion about the paradigm of ageing as well as the concepts of anti-aging medicine, its standards and technologies are highlighted in more than 20 chapters all written by international experts in regenerative medicine. Some of the topics covered in this book include:

• Ageing, aging and anti-aging: A Decalogue for anti-aging medicine
• Lessons from Sicilian centenarians for anti-aging medicine
• Molecular biomarkers and genetic aspects of aging
• Future of peptides in clinical practice
• Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection
• Tissue-specific autoantibodies in preventive medicine
• Chronic stress as a psycho-neuro-immunological dysfunction
• Gut-associated immune system and its health implications
• Regenerative medicine with platelet-rich-plasma
• Alzheimer's disease: Preventive and anti-aging neurology
• Autistic spectrum disorder and mitochondrial medicine
• Integrative hormonal approach in anti-aging medicine
• Preventive cardiology and phlebology
• Aesthetic and anti-aging medicine
• Preventive ophthalmology
• Preventive oncology
• Nutrition in healthy aging
• Physical activity and fitness paradigms for anti-aging and longevity

All clinicians working in anti-aging medicine - as well as ageing people – should read this book. It will hopefully set the "Standard of anti-aging medicine" and thus will be a tool in planning the challenges we all will face caring the ageing patients and creating the preventive programs for them.

Multiple sclerosis (MS) is a progressive neurological disease that affects millions of people worldwide. Currently, the causes of MS are still unclear and the cure of MS remains symptomatic, while the effectiveness of treatment varies widely among individuals. The clinical features and neurological defects derived from this progressive neurological disease are diverse since MS may affect the human central nervous system (CNS) at all levels from the brain to hen end of the spinal cord. Immunopathogenesis of MS involves many steps, including activation of peripheral leucocytes against putative CNS antigens, activated leucocytes with inflamed cerebral endothelial cells, the migration of activated lymphocytes and macrophages through the endothelium to the CNS environment, and further propagation of a massive immune response within the CNS, Such large-scale immune activation leads to loss of the myelin-oligodendrocyte complex. Various types of immune cells and mediators of the immune-inflammatory response actively contribute to the pathogenesis of MS. Genetic factors are also thought to play a central role in the development of most forms of MS. Axonal degeneration and neuronal loss are the core components of irreversible and permanent CNS atrophy and disability in MS.

This book provides a comprehensive overview of the current MS situation as researchers try to understand the process and develop treatments that can slow or stop the disease, possible repair the damage, alleviate specified symptoms, and improve the abilities of MS patients to function in everyday life. Various biological holistic approaches have been shown to slow disease progression in some patients, and the recovery rate of cellular mechanism in the brain and spinal cord has been accelerated, increasing the possibility of achieving complete balance of the disease state.

The panels review the background, focusing on novel strategies that are most likely to understand the biological mechanism of recovery and translate findings into alternative comprehensive approach to the MS management. The modality of such complementary therapies adds a new dimension, geared to further improvement in the management and sustain the acquired long-term results of MS. This books will necessary to MS researchers, research funder, healthcare advocate MS research and treatment, and interested patients and their families.

Authors: Dr. Glen Alvin, Dr. Vladimir Chernykh and Prof. Dr. Mike Chan

Dr. Glen Alvin, Prof. Dr. Mike Chan and Prof. Dr. Thomas Skutella

Clinics of Surgery, ISSN 2638-1451, Volume 5 Issue 8-2021, May 7, 2021

Published URL: http://clinicsofsurgery.com/COS-v5-1459.htm