Klotho protein: a multifaceted regulator in aging and cancer dynamics

A groundbreaking review article in Molecular Biology Reports maps out why the α-Klotho protein is fast becoming a keystone molecule for both healthy longevity and oncology! Co-authored by European Wellness founder Prof. Dato’ Sri Dr. Mike Chan along with an international team of researchers, the study reveals how Klotho might hold the key to aging and conditions such as cancer.

What makes Klotho so special?

• It acts like a control switch for major cell pathways – including Wnt, IGF-1, PI3K/AKT, and TGF-β – helping to prevent runaway cell growth and tissue damage.
• It has strong antioxidant and anti-inflammatory powers, which protect our DNA and slow down age-related wear and tear.
• In many cancers (like breast, liver, and T-cell cancers), Klotho levels are observed to drop. Restoring it may potentially hold the key to addressing cancer growth and spread.
• Researchers are developing cutting-edge ways to bring Klotho back – including gene therapy, peptides, and smart nanoparticles.

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