Restoring the Degenerating Brain: Mesenchymal and Neural Stem Cells in Neurotherapeutics

💡 About the Publication:

This powerful review explores how mesenchymal stem cells (MSCs) and neural stem/progenitor cells (NSPCs) offer transformative potential in the treatment of complex neurodegenerative and neuroinflammatory diseases such as Alzheimer’s, Parkinson’s, ALS, MS, stroke, TBI, and SCI.

These two stem cell types are uniquely positioned to:

✔️ Address key pathologies like neuronal loss, inflammation, and blood-brain barrier (BBB) dysfunction
✔️ Promote cell replacement, neuroprotection, synaptic plasticity, and remyelination
✔️ Deliver therapeutic effects through direct regeneration and powerful paracrine signaling
✔️ Reduce oxidative stress and neuroinflammation, while enhancing recovery through trophic and immunomodulatory actions

With insights from clinical and preclinical models, the article also compares the unique advantages and limitations of MSCs and NSPCs and provides a roadmap for optimizing their clinical translation

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