Mooren Ulcer

Mooren Ulcer is a rare, painful, and progressive autoimmune corneal disorder that affects the peripheral cornea without systemic association. This presentation explores its pathophysiology, clinical features, and therapeutic innovations. Beginning with its historical discovery in 1849, it highlights the condition’s epidemiology, showing higher incidence in Africa and Asia, and its pathogenesis—immune-mediated destruction of the corneal stroma leading to tissue loss and potential blindness. Symptoms such as severe pain, photophobia, and crescent-shaped ulceration are discussed along with diagnostic methods including slit-lamp examination and serological testing. Treatment strategies range from corticosteroids and immunosuppressants to surgical interventions like lamellar keratoplasty. The slides also examine advanced therapies such as stem cell transplantation, biologic agents, and regenerative medicine, alongside innovative holistic modalities including immunotherapy and nanotechnology-based drug delivery. The presentation emphasizes early diagnosis, multimodal management, and future prospects integrating AI-assisted diagnosis and personalized immunotherapy to improve prognosis and restore vision.