Polyarteritis Nodosa

Understand the complexities of Polyarteritis Nodosa (PAN) in this clinician-focused presentation by Prof. Dr. Mike Chan, tailored for rheumatologists, internists, and integrative medicine practitioners. PAN is a necrotizing vasculitis of medium-sized arteries that can present with constitutional symptoms, painful neuropathy, renal involvement (hypertension, infarcts), skin lesions (livedo, nodules, ulcers), and abdominal or cardiac ischemia. Diagnosis hinges on pattern recognition plus targeted testing—lab markers, imaging (CTA/MRA), tissue biopsy, and evaluation for triggers. Management pairs evidence-based care (glucocorticoids, immunosuppressants, antiviral therapy when indicated) with a holistic immune-restorative strategy: Autologous Active Specific Immunotherapy (AASI) to recalibrate aberrant immunity; PSC (Precursor Stem Cells) and GcMAF Forte to modulate immune balance; Thymus Therapy with MO Thymus and NOP Thymus to support central tolerance; and systemic support via Transfer Factors, MO STF, and NOP STF to reduce inflammatory flares and protect organ function.