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CELL THERAPY – CELLULAR & TISSUE XENOTRANSPLANTATION: Challenges, Progress & Current Applications

Author: Prof. Dr. Mike K.S. Chan, Prof Dr Michelle Wong, Dr Patricia Pan, Dr Roni Lara Moya, Prof Dr Thomas Skutella, Chen Rui, Sabine Conrad, Yvonne Chia, Clarice EA, Yee Hui Rong and Yenny Kenisi.
Published by: EUROPE BOOKS, UK
Medical Research: ISBN: 9791220146456

The team of researchers who collaborated with Dr. Chan, pioneer of these studies, has produced a document with a strong bibliographic depth for those who wish to explore the content.

As we read in the preface: “For more than a century, xenotransplantation has been viewed as a potential solution to address the scarcity of human organs and tissue which are available for allotransplantation.
However, due to numerous obstacles, including immunological rejection, regulatory restrictions, and ethical considerations; the progress of xenotransplantation has been stagnant and largely trapped in the preclinical stage. This book explores the challenges surrounding the field of xenotransplantation, looks into possible strategies to overcome them and discusses the potential and future of this field”.

Accurate images make it a very informative text.

Price: $25.00 – $50.00

Cell Therapy – Cellular & Tissue Xenotransplantation: Challenges, Progress & Current Applications

Cell Therapy – Cellular & Tissue Xenotransplantation: Challenges, Progress & Current Applications

Author: Prof. Dr. Mike K.S. Chan
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research:
ISBN: 9781803132082, eISBN: 9781803134260

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Cell Therapy – Cellular & Tissue Xenotransplantation: Challenges, Progress & Current Applications

English

CELL THERAPY – CELLULAR & TISSUE XENOTRANSPLANTATION: Challenges, Progress and Current Applications. The team of researchers who collaborated with Dr. Chan, pioneer of these studies, has produced a document with a strong bibliographic depth for those who wish to explore the content.

As we read in the preface: “For more than a century, xenotransplantation has been viewed as a potential solution to address the scarcity of human organs and tissue which are available for allotransplantation.

However, due to numerous obstacles, including immunological rejection, regulatory restrictions, and ethical considerations; the progress of xenotransplantation has been stagnant and largely trapped in the preclinical stage. This book explores the challenges surrounding the field of xenotransplantation, looks into possible strategies to overcome them and discusses the potential and future of this field”.

Table of Content

PREFACE ix
ABBREVIATIONS xi
CHAPTER 1: AN OVERVIEW OF XENOTRANSPLANTATION 1
Introduction 1
The Rationale of Xenotransplantation 2
Categories of Xenotransplantation . 3
Xenotransplantation – The Progress Since 1800 5
Xenogeneic Cell Therapy in Regenerative Medicine 9
CHAPTER 2: THE CHALLENGES OF XENOTRANSPLANTATION AND STRATEGIES TO OVERCOME THEM 11
Introduction 11
The Hurdles of Xenotransplantation 12
Immunological Barriers 13
Infectious Disease Risks 20
Strategies to Overcome the Hurdles of Xenotransplantation 23
Overcoming Immunogenicity and Rejection 24
Similarity Between Human and Animals of Different Species 36
Source Animal Characterization 43
Conclusion 44
CHAPTER 3: ETHICS AND REGULATIONS IN XENOTRANSPLANTATION 46
Introduction 46
Ethical Issues and Religious Views 46
Regulatory Approaches on Xenotransplantation 48
International Xenotransplantation Association 49
Regulation in the US 50
Regulation in the UK and Europe 51
Regulation in the Japan 53
Regulation in the China 54
Regulation in the South Korea 54
Regulation in the Australia 55
Conclusion 55
CHAPTER 4: THE POTENTIAL OF CELL THERAPY – CELLULAR AND TISSUE XENOTRANSPLANTATION 56
Introduction 56
Clinical Potential of Cell Therapy – Cellular and Tissue Xenotransplantation 57
Organ Reconstruction 58
Tissue Defects 59
Clinical Cellular and Tissue Xenotransplantation 60
Xenogeneic Cell Therapy and Autoimmune Tolerance 61
Advantages of Xenogeneic Cell Therapy 66
Conclusion 69
CHAPTER 5: FUTURE DIRECTION OF XENOTRANSPLANTATION 70
CHAPTER 6: CONCLUDING REMARKS 77
BIBLIOGRAPHY 78
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