Pico Cell Matrix of ACE Reno and its effect on Adenine induced chronic Kidney disease

About the Article:

Chronic Kidney Disease (CKD) is a progressive condition marked by nephron loss, fibrosis, inflammation, and impaired renal function. This review explores the Pico Cell Matrix of ACE Reno, a bioactive regenerative matrix derived from kidney, placental, atrial tissues, and mesenchymal stem cells (MSCs) and its potential to halt and reverse CKD pathology in an adenine‑induced animal model.

Key Themes Include:

• Organ‑specific regenerative potential: Pico Cell Matrix delivers peptides and signaling molecules that support nephron regeneration, organ repair, and anti‑fibrotic activity.
• Improved kidney structure and function: Treated kidneys showed restored glomerular architecture, enhanced podocyte integrity, and increased capillary density.
• Molecular mechanisms: ACE Reno modulated key pathways, suppressing TGF‑β and epithelial–mesenchymal transition, promoting mitochondrial repair via PGC‑1α, supporting angiogenesis (VEGF‑A/Ang1), and rebalancing antifibrotic and anti‑inflammatory signals such as miR‑29.
• Potential paradigm shift: These findings position ACE Reno’s Pico Cell Matrix as a promising organ‑specific, cell‑free regenerative intervention that goes beyond conventional palliative care.

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