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Insomnia: Integrative Approaches to Longevity & Regenerative Medicine

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Sleep is a fundamental biological function essential for physical and mental well-being. It is critical in memory consolidation, tissue repair, immune system regulation, and metabolic balance, contributing to an increased risk of cardiovascular disease, obesity, diabetes, neurodegenerative disorders and premature ageing. Sleep disorders—especially insomnia—affect millions worldwide, leading to profound consequences on daily life and long-term health. Insomnia, characterised by difficulty falling asleep, staying asleep, or waking too early, is more than an inconvenience. Modern lifestyles have exacerbated sleep problems, with artificial light exposure, increased screen time, and 24-hour work cycles disrupting natural circadian rhythms. These factors, combined with psychological stress, anxiety, and poor sleep hygiene, have led to an epidemic of sleep disturbances. Social jetlag—where biological clocks are misaligned with modern schedules—is particularly common in adolescents and professionals, worsening insomnia and leading to long-term health consequences. The book explores how technology, societal pressures, and environmental influences have reshaped sleep patterns and how individuals can restore balance through targeted interventions.

This book presents an integrative approach, combining evidence-based lifestyle modifications, cognitive-behavioral therapies, and biological interventions to offer sustainable solutions for sleep improvement. One of the key focuses of this book is the intersection of sleep science with regenerative medicine. Cutting-edge research highlights the role of cellular repair, neuroprotection, and overall vitality. The book also discusses the latest advancements in sleep-enhancing therapies, including nutraceuticals, peptide treatments, and biohacking strategies aimed at improving sleep architecture and circadian alignment.

By exploring the science behind insomnia and offering practical, integrative solutions, this book serves as a valuable resource for anyone seeking to improve their sleep quality and overall health. Whether you are a healthcare professional, researcher, or someone struggling with sleep disturbances, you will find the tools and insights to reclaim restorative sleep and enhance longevity in this book.

SKU: 9781662964947 Categories: ,

Description

Authors
Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina

Published by
EUROPEAN WELLNESS ACADEMY – Medical Research

Medical Research
ISBN: 9781662964947
eISBN: 9781662964954
Library of Congress Control Number: 2025939690
DOI: https://doi.org/10.69669/sl2184

Author Bio:

Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.

Dr Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy “He, who owns the youth, owns the future”, Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.

Table of Content

INTRODUCTION 1
CHAPTER I: NORMAL SLEEP 5
Why Is it Necessary for Humans to Sleep? 7
Genetics of Sleep 14
Sleep, Learning, and Memory 20
Effects of Sleep Deprivation on Risk of Diseases 24
Sleep Duration and Obesity 29
Sleep Deprivation and Its Link to Type 2 Diabetes 30
Sleep Deprivation, Heart Disease, and Hypertension 33
Sleep Deprivation and Mood Disorders 36
The Role of Sleep in Immune Function and Infection Response 39
The Paradox of Alcohol and Sleep: Initial Sedation and Subsequent Sleep Disruption 42
The Relationship Between Sleep and Life Expectancy 44
Pineal Gland 47
Melatonin Secretion 48
Other Effects of Melatonin 51
Physiology of Sleep 53
Rapid Sleep (REM) and Slow Sleep 62
Sleep Stages 66
Dreams 70
Hypothalamic Control of Sleep and Circadian Rhythm 75
Risk Factors of Sleep Disorders 82
Causes of Insomnia 92
CHAPTER II: SLEEP DISTURBANCES 97
Classification 97
International Classification of Diseases (ICD) 97
Diagnostic and Statistical Manual of Mental Disorders (DSM) 100
International Classification of Sleep Disorders (ICSD) 102
Common Types of Sleeping Disorders 106
Insomnia 106
Hypersomnia 107
Parasomnias 113
Apnea or Hypopnea in Sleep 116
Insomnia 121
Diagnosis of Sleep Disorders 126
CHAPTER III: BIOLOGICAL APPROACH 139
Brain Tissue Cells, Types, and Their Function 141
Advantages and Challenges of Different Cell Types 166
Neural Stem Cells 175
Targeted Precursor Stem Cells 184
Mesenchymal Stem Cells 185
Key Characteristics and Potential Benefits of Mesenchymal Stem Cells 186
Therapeutic Insights and Challenges 188
Induced Pluripotent Stem Cells 189
Embryonic Stem Cells 198
Precursor Stem Cells Definition and Function 200
Neural Stem Cells in Sleep Regulation 205
The Role of the Hypothalamus Cells 209
The Role of the Thalamus Cells 215
The Role of the Brainstem Cells 219
The Role of the Cerebral Cortex Cells 223
The Role of the Cerebellum Cells 226
The Role of the Amygdala Cells 228
The Role of the Hippocampus Cells 232
The Role of Pineal Gland Cells 237
The Role of the Spinal Cord Cells 239
The Brain Structures Responsible for Rapid Sleep 242
The Structures Responsible for Slow Sleep 245
The Role of Mitochondria and Mito-organelles in CNS 257
Mitochondrial Functions Relevant to Sleep Regulation 259
Mitochondrial Dysfunction in Sleep Disorders 260
Benefits of Mitochondrial-Targeted Approach 260
Stem Cell Therapy and Mitochondrial Transfer 261
Neural Nano Peptides 265
Role of Pineal Gland Peptides 266
Neural Peptides and Sleep Regulation 268
CHAPTER IV: PHYSIOTHERAPY 271
Continuous Positive Airway Pressure (CPAP) Therapy 271
Transcranial Electrostimulation 276
Magnesium and Bromide Electrophoresis 279
Aeroionotherapy 281
Electrobiosleep 283
Phototherapy 285
Darsonvalization 287
Holistic Integrative Approach 289
Nutrition and Diet 292
Cognitive Behavioral Therapy for Insomnia (CBTI) 297
BIBLIOGRAPHY 301

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Printed English (Paperback), eBook English

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