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Stem Cells in Regenerative Medicine: Carpe Diem – Carpe Vitam!


In most of the doctors’ perception the term ‘regenerative medicine’ is associated with tissue reconstruction after severe injuries, burns or trauma. And that is absolutely correct except the fact that tissues and organs deteriorate and lose their function not only due to mechanical or physical damage, but as a result of chronic diseases, inflammation, age-related degeneration as well as genetic abnormalities and cellular dysfunction. The profound understanding of tissue morphology on the cellular level and studying of the ontogenesis open magnificent opportunities to restoration of structural and functional integrity of human organism.

Throughout centuries scientists and healthcare practitioners were in a constant pursuit of longevity—from Avicenna and Paracelsus to Brown-Sequad, Serge Voronoff and Paul Niehans. Not so long ago, in 1990’s, when the term regenerative medicine was tailored by Dr. Leland Kaiser and propagated by William Haseltine it was considered to be a medicine of the Future, «a new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems», as Dr. Leland Kaiser described it. A new hope spurred up that almost any condition can be at least improved if not cured by means of regenerative medicine, including those cases where conventional medicine is powerless or ineffective.

The Future Dr. Kaiser was talking about is certainly a Present today. Though relatively small amount of practitioners are aware of today’s regenerative medicine capabilities and many still consider it more like science fiction.
This book reveals concepts and protocols of successful approach to regenerative medicine by means of stem cell therapy. It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.

Also available in Japanese edition! A World First “Stem Cells in Regenerative Medicine: Carpe Diem, Carpe Vitam!” highly regarded by the Japanese biomedical community as a ‘Bible of Stem Cell Therapy’. Fully translated to Japanese under the supervision of Prof. Dr. Isso Kimura, Edited by Keiko Kimura, Published in Japan by Sun Synergy Co., Ltd. Officially unveiled on December 18th, 2022 in Japan.

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SKU: ISBN978-1-83859-011-6 Categories: ,



(ISBN 978-1-83859-011-6)

It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.

Mike K.S. Chan & Dmitry Klokol
ISBN 978 1838590 116

Table of Content

Foreword xv
Introduction xix
PART 1 1
Chapter 1 3
From Embryology to Regenerative medicine 3
History of stem cell research 6
Stem cell biology 15
Choice of Stem Cells in Wellness and Biological medicine 29
Chapter 2 33
Animal sources of stem cell xenotransplants 36
Tissue procurement and cell culturing 41
Archiving of medical records and specimens from animal source 44
Quality control 45
Release and labelling of precursor stem cells 47
Chapter 3 51
Genotype-phenotype distinction and relationships between donor cells and recipient 52
Epigenetics and Stem cells 57
Immunology and genetics in Stem cell therapy 61
Chapter 4 83
Chapter 5 109
Homing and migration of fetal precursor stem cells 110
Adhesion, binding and interaction of fetal precursor stem cells 112
Paracrine mechanisms of fetal precursor stem cells 115
Soluble paracrine factors of fetal precursor stem cells 117
Insoluble paracrine factors of fetal precursor stem cells 118
Further considerations on immunogenicity of Fetal Precursor Stem Cells 122
Chapter 6 122
Autologous stem cells and history of its transplantation 128
Autologous Stem Cell Transplantation 132
Very small embryonic stem cells (VSELs) 136
Clinical applications of Autologous SC transplantation in different diseases 147
PART 2 169
Chapter 7 171
Chapter 8 185
Outlook on the etiology and pathogenesis of ASD. Role of genetics and immunity in development of Autism and ASD 186
Role of imaging studies and biological markers in Autism and ASD and its links to symptomatology 188
Integrative therapeutic protocol for Autism and ASD 191
Chapter 9 203
Social and general medical aspects of AD 203
Therapeutic strategies in AD 218
Stem cell therapy in treatment of AD 225
Mito Organelles™ CNS Neuropeptides in management of AD 228
Chapter 10 233
Social and general medical aspects PD 233
Protective factors against PD 240
The role of mitochondria in PD 243
Clinical forms of PD 246
Clinical diagnosis of PD 252
Treatment strategies in PD 253
Treatment of Parkinson’s disease with precursor stem cells 257
Neuropeptides Mito Organelles™ CNS in management of PD 265
Transcranial electric and magnetic stimulation of the brain (TCS) 266
Chapter 11 271
Social and general medical aspects of stroke 271
Risk factors and symptoms of stroke 277
Post-stroke rehabilitation 286
Stem cells and cell therapy in management of stroke 292
MO CNS neuropeptides in management of stroke patients 297
PART 3 303
Chapter 12 305
Morpho-physiology of pancreas and general medical aspects of diabetes mellitus 305
Stem cells and live cell therapeutic approach in management of diabetic patients 323
Chapter 13 335
Pathogenesis of cardiomyopathies and cardiac regenerative potentials 335
Cell therapy as treatment modality in cardiomyopathy 359
Chapter 14 371
Mechanisms of kidney regeneration 372
Stem cells in kidney’s regeneration 372
Stem cells xenotransplantation in management of CKD 377
Chapter 15 389
Pathogenesis of liver disease 389
Cell therapy based treatment of liver disease 402
Chapter 16 421
General medical considerations on muscular dystrophies 421
Pathogenesis and diagnostics of Muscular Dystrophy 424
Novel treatment strategies in Muscular Dystrophy 428
Chapter 17 439
Retina’s morphology and pathogenesis of retinopathies 439
General considerations of cell therapy based treatment strategies in retinopathy 445
Bioengineering in Clinical Trials using Human Pluripotent Stem Cells 446
Precursor Stem Cell/ Live Cell Therapy in Retinal Diseases 452
Cell-based therapies for retinal pigment epithelium replacement 468
Cell-based therapies for photoreceptor replacement 471
Chapter 18 475
Morphophysiology of placenta and physiological background of placental therapy 475
Main characteristics of placental therapy products 479
Biological and medicinal properties of placental extracts 483
Placental therapy in treatment of hair loss 486

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  1. NetGalley

    I have only looked at the first few chapters of this amazing book. It’s definitely one that I will be looking at and digesting at a slow pace.
    The first few chapters were more of a getting to know you by the authors and what their research is about.

    I have 2 children at uni, one doing Nursing and one doing Biology, this book will definitely help me keep up with their conversations.

    I will update this review when I have read more as I can see that it’s going to be fascinating.

  2. Nemo

    This is a seminal monograph on the subject of the therapeutic application and use of stem cells in “regenerative medicine.” The science described within the pages of this text may be leading edge, but Chan and Klokol have attempted to keep the information accessible to the average reader. However, in some parts the comprehension of the complex science may be challenging. Research scientists and students of medical research may gain the greatest benefits of this work.

    The text guides you through the multiple applications of the utilization of Stem Cells and the medical illnesses that may be treated by the use of ‘Xenogeneic Cell Therapy.’ The authors posit the limitations and benefits of the scientific method as it relates explicitly to its use in human subjects. There is a brief description of xenotransplantation in the treatment of cells requiring regenerative assistance in a range of degenerative conditions through cross-species donated cells. Significant importance is placed in the use of cross-species hosts to be Scientific Pathogen Free Animals (SPF – Animals) through the use of ‘Closed Colony’ and proven clinical methods.

    Stem Cells in Regenerative Medicine describes the merits, the problemata, and the detailed methodologies of regenerative therapies. The book is replete with beautiful color illustrations that includes the Cell Cycle and the illustrations of the Noble Prize Winner, Günter Blobel, for Physiology or Medicine in 1999. His thesis is on how the distribution mechanism of biological active transport cells migrate, how proteins contain signals inside that direct their location in a destination cell, and how they are transported and where they may migrate to.

    I found the Chronology of the development of stem cell research and application to be compelling reading.

    Simply the most comprehensive book on the subject of Stem Cells as applied in ‘regenerative medicine,’ and most certainly the best illustrated. The illustrations combined with Chan and Klokol‘s vivid written communication provides you with an invaluable tool in comprehending the ground breaking subject of Stem Cell Therapy.

  3. Academician Chen Runsheng

    Do we need another book on stem cells? There are many books that cover the theoretical aspects of the discipline and others that attempt to collate protocols using umbilical cord blood cells or adipose-derived MSCs. Nevertheless, the new book Stem Cells in Regenerative Medicine: Carpe diem, carpe vitum! succeeds in combining both of these characteristics, providing not only a clear account of the scientific discoveries underpinning stem cell biology, but also a useful range of laboratory and clinical involving fetal precursor stem cells. The book is written in very comprehensive and appropriate for all levels of reader’s expertise in the field or for a scientist or practitioner working with stem cells.

    The international team editors are all coming from various institutions such as FCTI Stem Cells lnc., Baden Laboratories, European Wellness Group of Centers worldwide and European Wellness Academy – Germany, Stellar Biomolecular Research – Germany and Innovations. The book is divided broadly into clearly defined sections: an introduction; basic and general science of cell biology and stem cells, two sections on the culture and characterisation of various types of stem cells; regulatory aspects of stem cell research and applications; and two sections covering more recent technologies and applications relevant to the fetal precursor stem cells.

    In the introduction, the authors have managed to distil over 100 years of stem cell advances in just a few pages of text. The sections containing protocols are excellent and provide the perfect framework for experimental and clinical work with stem cells. Each chapter is devoted to a separate technique and begins with an extremely helpful overview that underlines the basic steps, and importance, of each protocol.

    Much has been made of the potential applications of fetal stem cells in treatment of neurodegenerative diseases. Interesting topic of clinical applications of placental therapy. The final section deals with these applications. The authors manage to encapsulate the major recent breakthroughs and future prospects for cell replacement therapies in ectodermal, mesodermal and endodermal tissues. To the authors, a great book! We look forward for more from you both!

  4. Academician Fan Daiming

    Stem cells in regenerative medicine is an interesting read consisting of compilation of chapters on the latest advances in stem cell research by international experts in the field. Both authors Prof. Mike Chan and Prof. Dr. Dmitry Klokol are well-known experts in the field of cell therapy and stem cell research. The editor-in-chief, Dr. Dmitry Klokol is a surgeon with
    extensive experience in surgical practice, who turned into regenerative medicine. Dr Klokol pioneered in creating novice therapeutic protocols of treatment for a number of chronic degenerative diseases. Prof. Mike Chan is a respected expert in cellular therapy and stem cell transplantation product formulation, innovator in cell therapy, and a technical expert in cell therapy manufacturing. Prof. Mike Chan is a Founder of the companies conducting stem cell research, formulation and manufacturing of products for cell therapy and regenerative medicine, as well as medical service in numerous facilities all over the World.

    The entire team of contributing authors have been actively involved in stem cell research for antiaging, preventive and regenerative medicine. Several chapters are of great relevance to researchers in the field of treatment of chronic degenerative diseases, which otherwise considered as incurable from the point of view of conventional medicine. Some provide a comprehensive overview to new researchers in the field. Others provide extensive details of the protocols related to stem cells procurement, processing, and application. Both medical practitioners and researchers in cell biology and regenerative medicine will find content that interests them.

    The book contains many elegant and descriptive images and figures. The tables are generally easy to understand. The book recommended for a broad spectrum of medical-related audience. Wonder, entertaining and enriching!

  5. Academician Zhuang Wenying

    This book has opened up a spectrum for me in understanding stem cells in regenerative medicine. The dilution of the term stem cells has been addressed here cohesively by evaluating the role of stem cells in xenotransplantation, the way it is in the authors’ decades of work.

    The growing breadth of neurodegenerative diseases and the therapeutic functionality of stem cells’ value in managing other morbidities especially chronic kidney disease gained my attention. The common thread and the table of contents keeps referencing effortless. This could only be possible if the reader is from the medical & scientific fraternity, earning the book a gold star for adhering to medical content by organisation.

    Being a progressive book of sciences, it has its own limitations addressing depth but this book has given me the perspective to dive deeper and work with the authors in witnessing the miles further. Now, this conviction itself de-limits the limitations. Yet another exciting chapter opens in the realm of Biological Regenerative Medicine. Kudos!

  6. Dr. Abdul Halim Abdul Jalil, Consultant Pediatrician

    The aim of regenerative medicine is to regenerate dysfunctioning tissues and organ systems by implantation of cells, particularly stem cells that can stimulate even wider regeneration. Contemporary research projects focus mainly on human derived stem cells. These include the use of soluble molecules, gene therapy, tissue and cell genetic engineering. But there are limitations even in the use of autologous stem cells. Although much has been learned from fundamental science, effective and safe clinical protocols to treat the many currently untreatable medical conditions such as degenerative neurological conditions, complications of diabetes mellitus type II, trauma, and aging diseases etc. are still not forthcoming.

    In reality live cell therapy using fetal tissues of animal origin has been used by physicians successfully, particularly in Europe for more than a century. Although this has been described as a very safe form of biotherapy with positive outcome in the treatment of neurodegenerative, systemic degenerative and chromosomal/genetic disorders this form of treatment is still not in mainstream medicine. Many groundbreaking research published on cell therapy in the last century which uses fetal precursor cells of animal origin have been either ignored or dismissed. Hence, I applaud the publication of this book by Prof Dmytri Klokol and Prof. Mike Chan. Prof Mike Chan and Prof Michelle Wong have been my close associates since I started my journey almost two decades ago on live cell therapy using fetal precursor stem cell xenotransplantation (FPSCXT). Their commitment to research and training of scientists and physicians in the field of regenerative medicine is truly commendable.

    Discussions in this book include the use of fetal precursor stem cells of animal origin. The general protocol of treatment presented in this book- diagnosis, detoxification, repair and rejuvenation is a personalised approach to medicine. This requires a detailed assessment to recognise, correct physiological dysfunctions, remove/treat the causes. This is critical for optimum outcome of treatment. Contemporary medicine is now in the realm of systems biology(medicine) focussing on understanding of the entire biological systems to find health solutions. We now have new research tools such as genomics, systems biology, molecular imaging techniques and many others which were not available to earlier researchers. It is hoped that this book will generate interest among fundamental scientists and physicians to revisit research on cell biology and cell therapy with the degree of scientific sophistication now possible to achieve this aim.

  7. Dr. Cathleen Gerenger DC, FIAMA

    It is with great pleasure that I write this foreword for Professor Mike Chan. It is an honor and privilege to share my respect for Professor Chan’s determination to pursue cell therapy research and teach the world what he has learned in the regenerative therapy arena. Professor Mike Chan’s tireless research holds the foundational key to unlock your body’s health potential.

    My name is Dr. Cathleen Gerenger. I have been in private practice in Florida, USA for over twenty years. I received my doctorate in Chiropractic Medicine at the age of twenty-four. My love for nutrition, hormonal health, and regenerative medicine led me to connect with Professor Chan. I had the pleasure of meeting him during my International Speaking Venue in Malaysia. Professor Chan and I clicked immediately when we shared our passion regarding regenerative medicine. Professor Chan invited me to visit European Wellness, in Kota Kinabalu, Malaysia, one of the 26 clinics he is involved with. I was impressed by the professionalism of his team and witnessed the meticulous details his well-trained staff provided when it came to patient care. When I returned to the United States, still inspired by my observations, I started to implement Professor Chan’s protocols into my clinical practice.

    Professor Chan and co-author Dr. Dmitry Klokol have written several books. Stem Cells In Regenerative Medicine – Carpe Diem – Carpe Vitam. is a must read! I feel that the wealth of knowledge this book provides will be a great opportunity for doctors, health care providers and medical schools to incorporate in their medical practices and medical school curriculum.

    Thank you, Professor Mike Chan for your friendship, zest for life and above all, your love for humanity.

  8. Dr. Desirée Cox, MD, PhD

    The history of medicine is full of examples of innovators seeking to create new therapeutic approaches to help patients achieve health and wellness. Stem Cells in Regenerative Medicine: Carpe Diem – Carpe Vitam! by Mike K. S. Chan and Dmitry Klokol presents a natural history of the evolution of an approach, which they’ve developed over close to three decades, of integrating the best Western or ‘European’ treatment modalities with certain components of traditional Asian medical systems. ‘European Biological Wellness’ is the term developed by the authors to describe an approach characterized by a four-step signature algorithm – ‘Diagnose, Detox, Repair, and Rejuvenate’ or DDR – in which stem cell therapy forms a core component of their therapeutic approach.

    The promise of cell reprogramming has long been the holy grail of medicine. It captures the core essence and almost mythical potential of the ‘fountain of youth’ whereby, as human beings, we are able to ongoingly heal our physical body and ourselves. In many ways, the field of stem cell and regenerative medicine captures the imagination of the public because of its potential to deliver on this promise.

    In my personal view, the field of stem cell and regenerative medicine in its current state has some way to go before it fulfills its potential. That said, regenerative medicine is rapidly evolving, driven as much by critically important global safety and efficacy regulatory requirements as it is by the shifting landscapes of science and technology, not to mention public education and awareness. In recent times, questions as fundamental as ‘what is a stem cell?’ have come under scrutiny and are hotly debated in certain scientific circles. Indeed, I believe we will likely see a revision and re-defining of many terms, definitions, and hypotheses as we move towards a more unified, interoperable system and codex of the regenerative sciences.

    As founder and CEO of The HEALinc and The HEALinc Future Health Innovation Summits, I believe that during this period of accelerated evolution it is important to learn from and about the perspectives of innovators in stem cell and regenerative medicine across the globe. A Unified Sciences of Regenerative Health that offers patients safe alternatives for their healing process will require the wisdom of many healthcare providers, innovators, entrepreneurs, and more.

    By sharing their extensive experience and knowledge of close to three decades in the regenerative medicine field – and by outlining the natural history of their approach in A Comprehensive Guide to Biological Medicine and Wellness and Stem Cells in Regenerative Medicine: Carpe Diem – Carpe Vitam! – innovators like Professor Mike Chan and Dr. Dmitry Klokol are recognized as pioneers in the field, making invaluable contributions to a broad spectrum of medical-related audiences and the future of health. It is critical that Professor Chan, Dr Kolkol and the European Wellness team use the descriptive account of the DDR algorithm and the clinical experience of stem cell therapy outlined in this book form the basis of more intensive scientific research and clinical trials to aimed at advancing the field.

  9. Dr. Isso Kimura, DDS, PhD

    The “Stem Cells in Regenerative Medicine” book, co-authored by Dr. Chan and Dr. Dmytro, is an in-depth guide to the history, practical theory, and ethics of cell
    therapy and to the treatment methods of all intractable diseases that we face today at our medical practice.

    “Life is a learning process.” Under Dr. Chan’s guidance, in 2020, I founded an academic society in Japan to work with physicians and dentists in the practice and study of regenerative medicine. Through this activity, I hope to see the fusion of the medical community in Japan, which has made pioneering contributions in the field of stem cell research, with the clinical practice field of regenerative medicine, in which Dr. Chan has devoted his life and passion, to bring about medical innovation. I have no doubt that this book will serve as a messenger in the mission of medical innovation. “When there is a fusion of an invention and an issue which society needs to address, it will bring about a new wave in the society, which will create new values and bring happiness to mankind.”

    This book will be of great value to those who seek longevity with high quality of life and to the doctors who support people to have the quality of life they want.

  10. Dr. Michael Papacharalambous MD PhD

    As chief physician in Metropolitan hospitals (approximately 1500 beds) in Greece and serving as General Secretary of the European Society of Preventing and Regenerative Medicine (ESAAM) responsible for the clinical applications in regenerative medicine we were working on how to generate healthy cells to replace diseased cells. In theory stem cells can be guided into becoming specific cells that can be used to regenerate and repair diseased or damaged organs and tissues in persons.

    From the book I understood why stem cells that come from bone marrow or blood in transplant procedures to treat diseases of blood cancers are successful and why trying to treat advanced degenerative nervous system diseases as Multiple sclerosis, Parkinson’s or Lou Goering’s with stem cells from skin or fat had partial or no success.

    I recommend this book to be read by all clinical physicians and scientists in biology in depth it has all the information they need for a successful journey in the medicine of future. It has all the information they need to understand from basic principles to advanced technology and education. I am happy to collaborate with Professor Mike Chan in Our ORTHOBIOTIKI clinic in Greece and implementing regenerative protocols.

  11. Dr. Orn Adalsteinsson

    The “Stem Cells in Regenerative Medicine” Book is an outstanding presentation of what can be achieved in novel therapies that involve cellular and non-cellular biologics with targeted approach for personalized human health improvements. The book authored by Prof. Mike Chan and Dr. Dmitry Klokol provides numerous case studies that show how stem cells as integrated with their four step personalized clinical protocol – DDRR (Diagnose, Detox, Repair, Rejuvenate) – can provide for advanced achievements in difficult to treat human diseases that the conventional medicine has not been able to touch.

    I had the privilege of meeting with Prof. Chan and Dr. Klokol in 2018 at a technical conference in San Diego, where I got my first introduction to their work. I was totally intrigued to learn that Prof. Chan and his wife Dr. Michelle Chan have been, for the past 35 years, pursuing their technology dream of using cellular and non-cellular biologics for human health. The effort has
    resulted in a technology empire that is being applied at numerous countries around the globe.

    The Stem Cells in Regenerative Medicine book is their latest book with multiple case studies demonstrating the breakthroughs that can be achieved. The book provides details of the strong regulatory components of their stem cell efforts. All of their cellular biologics are produced in GMP (Good Manufacturing Practices) compliance facilities where the materials can be reproducibly manufactured with the guarantee of being void of multiple specific diseases. Due to the increasing global emphasis on regulatory requirements, Team Mike and Dimitry is embracing the opportunity to intensify their scientific efforts including clinical studies and expansion into the peer reviewed publication field.

  12. Dr. Untoyo Wibowo SpAK

    The world of medicine and wellness are always evergrowing, especially nowadays with more advanced technology and researches. These breakthroughs in the field of medical has always fascinate me and encourage me to seek more knowledge regarding it. In all my 15 years of friendship with Prof Dr Mike Chan, it has always been a real pleasure discussing with him about innovations in the field of medicine, especially regenerative medicine and cell therapy. Hereby I congratulate him for his books and profoundly appreciate the knowledge shared within these books.

  13. Dr. W . Andralia Kartolo, MSc (UK), MD

    Prof. Dato’ Sri Dr. Mike Chan has never stop amusing me and the whole world in Antiaging Society. His works are always so profounding and mind-blowing. Thank you for sharing your magnificent creations with us. It has been an honour to write a sincere foreword to your Stem cell, Biological wellness and Cell membrane books.

  14. Her Holiness Sai Maa, MD

    Mike is very devoted, dedicated, service oriented, ethical, humble, high quality and high energy. He is like a “chef d’orchestre”, the way he sees substance and creates it. He creates masterpieces. He is so passionate, and his style of work resonates with my passion and work to serve humanity to be happier and healthier.

    He is like an artist of scientifically grounded information, of life extension as an experience. He likes exploring on a cellular level and structure. He is one who can really guide the stream of medicine right now, for the medical community to shift from an old medical paradigm to the next level, to see patients as whole, holistic in its full spectrum. He is someone who can bring the light of each cell in the physical body to surface. For someone as myself who is always looking for efficacious solutions to live a longer, gracious, fulfilling life expression, solutions that are cutting edge medically, scientifically and esoterically with all the modalities that I see in myself, I appreciate that about Professor Mike Chan.

    I appreciate his entrepreneurial mind, youthful and visionary, using protocols as I used to when I had my practice: being bold on a cellular level and structure. He understands the quantum behind everything else. He represents for me an example of the new medicine system, new medicine protocol. The beauty of him is that he has the power to bring the paradigm of the new diagnosis, the new detox system, the repair, the rejuvenation, the regeneration, the hormones, all advanced techniques from dark field to high level of colonics, IVs, nutrients, hyperbaric, any device including the subtleness of peptides work in all its variety. He is the example of the real medicine in its full spectrum, all the way from organs and glands to neurogenerative.

  15. Michele Hughes

    Early in my Life, I recognized that one of my passions is to inspire and influence others to be the best version of themselves and for me to be a teacher, influencer and role model for health and well-being. Imagine my delight when I was introduced to the CEO of European Wellness, Professor Dr. Mike Chan, and his international Group Medical Director, Dr. Dmitry Klokol, and to their exciting new books(*1).

    Their collaboration is a masterpiece of scientifically grounded information, and of their life long exploration and experience aimed at teaching and guiding the medical community and the lay person who are looking for efficacious solutions to living a longer and healthier life using cutting edge scientific and aesthetic modalities. Prof. Mike Chan is a tireless, humble entrepreneur and visionary whose youthful energy and accomplishments are proof that his protocols work! Anyone who tries their therapies and products, and visits any of their 26 centers, can attest to their dedication to quality and service.

    They say there are no accidents in life, and for this “happy accident“ of interaction with these two fine gentlemen, I am eternally grateful.

  16. Prof. Dato’ Dr. Chin Yew Sin, JP

    The history for a human being to quest for a immortality elixir that could enable him to live forever dated more than 2,200 years ago. Qin Shi Huang was the founding father of the Qin Dynasty and the first emperor of a united China. From 247 to 221 BC he was the King of Qin State. He became China’s first emperor when he was 38 years old after the Qin State had conquered all other Warring States and unified the whole of China in 221 BC. After he had founded the Qin Dynasty, he built the Great Wall, he wanted his empire to last forever and he wanted to live forever also. Newly discovered documents shown that 2,200 years ago, he even issued an executive order to look for a elixir that would enable him to have an eternal life. He sent Taoist alchemist Xu Fu to the eastern seas with 500 young men and 500 young women to quest for the elixir in the legendary Penglai Mountain, but returned without getting it. Xu Fu set sail on a second voyage with 3000 young girls and boys, but they never ever returned, instead, Xu Fu found Japan.

    That was the history for human beings to search for elixirs for immortality a few thousand years ago, however, the quest never stops there since then until now. The dream for a human being to live forever or at least to live as long as possible was/is a common desire of all human beings in the past and present time. With advances achieved in the field of Stem Cell Technology recently, it is not a dream anymore for a human being to live beyond 100 years old! We don’t have to go too far away places to search for the immortality elixir as compared with the Qin Shi Huang’s time, we just have to look for Prof. Dato’ Sri Dr. Mike Chan, an International Renowned Stem Cell Expert, he will be able to make you look younger, healthier and live longer also!

    Stem cells in particular, Precursor (Progenitor) Stem Cells or Progenitor cells are the most vital cells that keep our organs active from degeneration with age as they are targeted at specific organs. After 60 years old, we only have 5% of stem cells left only in our organs, thus we need to inject stem cells to rejuvenate ourselves! I highly recommend the books jointly written by Prof. Dato’ Sri Dr. Mike Chan & Prof. Dr. Dmytro Klokol on biologic medicine especially regarding the knowhow on stem cell technology. These books are well written by using a simple language and presented in a structured as well as coherent manners that will enable both experts and laymen to derive immense benefits from reading these books.

  17. Professor Dr. Anam Kour, MD, PhD

    When I was first introduced to this newly published book in 2019, I experienced that eureka moment – that “That’s it – I found it” moment after years of practicing age management and regenerative medicine. It has been invaluable in my daily clinical practice. It is a reliable authority in this evolving and expanding specialty branch of frontier medicine. It has become a constant reference material since.

    Being in medical practice the last 41 years, I reflected back on some of the major medical advances of the past decades. In December of 1954, Dr. Joseph Edward Murray of Boston, performed the first truly successful human kidney transplantation. Thirteen years later, in December of 1967 Dr. Christian Barnard of Cape Town carried out the first human to human heart transplant. These were significant medical breakthroughs in medicine, and herald a new bold field in human whole organ transplantation.

    In 1981 two scientists, Martin Evans at Cambridge, and Gail Martin in California, in their separate research, derived pluripotent stem cells from mice embryos – the first embryonic stem cells ever to be isolated. Seventeen years later, in 1998, James Thomson and Jeffrey Jones created the first batch of human embryonic stem cells, derived from early embryos. These again were significant advances in medical science that paved the way for stem cell therapy in subsequent years.

    This new field of stem cell biology and regenerative medicine is neither taught in medical schools nor is the knowledge available in mainstream medicine. Current practicing doctors, be they general practitioners or super specialty specialists, are neither taught nor exposed to stem cell medicine. They oftentimes read cursorily at the periphery or gather bits and pieces of information from the media. Hence the time is ripe for a book as this to be presented to the medical fraternity.

    This book, Stem cells in regenerative medicine, is structured, organized, comprehensive, and provides a syllabus for learning. It is a ready source of knowledge and reference materials. Readers will appreciate the latest research materials that were incorporated and the new clinical applications across the spectrum of diseases. This book will set the standard against which other future publications will be judged

    Contemporary medicine is focused on pathological diagnoses followed by disease eradication. For chronic diseases i.e. diabetes mellitus and hypertension, it is maintenance and damage control. Stem cell therapy has a different focus. It is a new dimension in treatment – that of repair of sick cells, reversal of degenerate cells, and regeneration of lost cells.

    This book is aimed at practicing clinicians, be they specialists or general practitioners. Regardless of their interest in stem cells, each practicing physician should have a personal copy, without which, these doctors risk being left behind. It is hoped that this book will pique the interest of many clinicians, leading and guiding them to offer a higher level of care to their patients.

    I congratulate the authors for this magnificent and timely book that the medical fraternity, knowingly or unknowingly, has been waiting for.

  18. Prof. Dr. Deby Vinski, Msc, PhD

    As an ingroup member of “Regenerative Medicine and Stem Cell Profession”, we have obviously digested lot of professional literatures in these fields. The book of Prof. Dr. Mike K.S. Chan & Prof. Dr. Dmytro Klokol however, contains new approaches and values. The systematic approaches made it easy to uncover stem cell and regenerative medicine. The contributors deserve thumbs up for their works. It fit nicely with the motto “Carpe Diem – Carpe Vitam” toward the new roles of regenerative medicine and Stem Cells. It’s a great book!

  19. Prof. Yin Dakui

    Recent advances in the fields of medicine and technology have led to the development of stem cell therapy. A stem cell is a cell that has the potential to develop into many different types of cell in the body. It has the ability to divide and copy itself and at least one other specialized type of cell. Precursor stem cells are defined on their differentiation pathway. Stem Cells in Regenerative medicine: Carpe Diem, Carpe Vitum was written to provide information about the development of stem cell therapy, which can be used in the fields of research and medicine. The main goal of the book is to provide readers with an overview of the scientific facts about precursor stem cells and its promising effects on the human body, as well as on the creation of new drugs and medicines. The book also highlights the ongoing clinical research into stem cells and lists the therapies whose effectiveness is being investigated. Stem cells in particular, Progenitor (Precursor) Stem Cells was revealed in such an exhaustive manner here.

  20. Professor Yu Xiaodong

    “Stem Cell in Regenerative medicine: Carpe Diem, Carpe Vitum” covers contemporary and emerging areas in precursor stem cells original scientific data reports, protocols, novel hypotheses and recommendations for applications. The scope related to stem cells is broad and includes topics in stem cell biology covering basic, clinical, biotechnology, regulatory, and ethical aspects of stem cells and fetal precursor stem cells particularly, as well as adult stem cells, induced pluripotent stem cells, and diseases where stem cell anomalies play a key role and related matters. All chapters are providing novel insights based on new experimental and clinical data. Literature data, scientific research review and hypotheses are providing syntheses of current concepts in the field and discuss emerging issues and controversies around stem cells. The nature of the topic or idea being discussed dictates appropriate choice of stem cell therapy, which arguably is targeted fetal precursor stem cell therapy.

    Fetal precursor stem cell therapy is based on tissue specificity and ability of the cells to perform homing – migrate and settle in the corresponding specific tissues with further proliferation of the new cells as well as instigating tissue repair and remodelling via the paracrine effect. Protocols will help accelerate studies in the field, by providing practical and step by step descriptions of established or emerging protocols and techniques of utility for both established and novice investigator. Kudos to the 2 authors!

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