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Concussion: The Hidden Trauma of Contact Sports and the NFL

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Concussion – The Hidden Trauma in contact Sports and the NFL –  Concussion and mild traumatic brain injury (mTBI) represent a spectrum of neurological injuries that have gained unprecedented attention in recent decades, particularly within the realm of sports medicine. The recognition and understanding of concussion symptoms have evolved dramatically, driven largely by high-profile cases in professional sports, especially the National Football League (NFL), and mounting scientific evidence about the serious nature of these seemingly “mild” injuries.

The symptomatology of concussion is complex and multifaceted, encompassing physical, cognitive, emotional, and sleep-related manifestations that can vary significantly between individuals and across different contexts. In sports settings, particularly in contact sports like American football, the presentation and recognition of these symptoms carry unique challenges and implications that extend far beyond the playing field.

This book provides a comprehensive examination of concussion symptoms, with particular emphasis on sports-related concussion and the landmark developments in understanding that have emerged from NFL research, policy changes and holistic approach of its management. The evolution of symptom recognition in professional football has not only transformed how we approach sports-related brain injury but has also influenced broader medical understanding of mild traumatic brain injury across all populations.

SKU: 9781662970504 Categories: ,

Description

Authors
Prof. Dr. Mike K.S. Chan, Leigh Steinberg and Dr. Dina Tulina

Published by
EUROPEAN WELLNESS ACADEMY – Medical Research

Medical Research
ISBN: 9781662970504
eISBN: 9781662970511
Library of Congress Control Number: ##

DOI: https://doi.org/10.69669/ox9567

Author Bio:

Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.

Leigh Steinberg is a legendary sports agent, entrepreneur, and Chairman of Steinberg Sports and Entertainment, widely known as the real-life inspiration for Jerry Maguire. He has represented over 300 professional athletes—including 64 NFL first-round picks, 8 number one overall selections, and 12 Hall of Famers—and has negotiated contracts exceeding $4 billion while directing over $1.2 billion to charitable causes. A UC Berkeley graduate, Leigh is also a philanthropist, media personality, and author. He recently established The Leigh Steinberg Foundation for Concussion, Traumatic Brain Injury, and Brain Health to continue championing brain health and making a lasting difference in athletes’ lives.

Dr. Dina Tulina is a Medical Advisor and physician specializing in anti-aging, regenerative medicine, and comprehensive wellness. She integrates preventive, biological, and natural care to promote longevity and vitality beyond conventional practice. At European Wellness Global, she contributes to biomedical innovation with holistic approaches and the translation of research into practical applications. Guided by her belief that true health is balance and vitality, and functional longevity, Dr. Tulina is dedicated to shaping the future of personalized and preventive healthcare.

Table of Content

EDUCATIONAL DISCLAIMER IX
PREFACE XIII
ABOUT THE AUTHORS XV
CHAPTER I: CONCUSSION – THE HIDDEN TRAUMA IN CONTACT SPORTS AND THE NFL 1
Historical Context and the NFL Concussion Crisis 2
Core Symptom Categories of Concussion 4
Physical Symptoms 4
Cognitive Symptoms 6
Emotional and Behavioral Symptoms 8
Sleep Disturbances 9
Sports-Specific Symptom Considerations 10
Contact Sports Symptom Patterns 10
Position-Specific Symptom Variations 11
Return-to-Play Symptom Considerations 11
The NFL Concussion Protocol and Symptom Assessment 13
Evolution of Assessment Methods 13
Independent Neurological Consultants 13
Technological Advances in Symptom Detection 14
Acute vs. Delayed Symptom Presentation 14
Immediate Symptom Recognition 14
Delayed Symptom Development 16
Symptom Evolution During Recovery 16
Long-Term and Persistent Symptoms 16
Post-Concussion Syndrome in Athletes 16
Chronic Traumatic Encephalopathy 17
Neurodegenerative Disease Risk 17
Symptom Assessment Tools and Protocols 18
Standardized Assessment Instruments 18
Computerized Neurocognitive Testing 18
Biomarker Development 21
Gender and Individual Differences in Symptom Presentation 21
Emerging Research on Female Athletes 21
Age and Experience Factors 22
Cultural and Psychological Factors 22
Impact of Repeated Concussions on Symptom Patterns 22
Cumulative Symptom Effects 22
Subconcussive Impact Effects 24
Second Impact Syndrome Risk 24
Technology and Innovation in Symptom Detection 25
Wearable Technology and Monitoring 25
Virtual Reality and Assessment 25
Artificial Intelligence and Machine Learning 26
Prevention and Management Strategies 26
Rule Changes and Equipment Innovations 26
Education and Culture Change 27
Medical Protocol Evolution 27
CONCUSSION AS A MILD TRAUMATIC BRAIN INJURY 29
EPIDEMIOLOGY OF CONCUSSION 33
Global and National Incidence Rates 35
Age and Sex Distribution 35
Concussion in Sports and Recreation 36
Occupational and Military Contexts 37
Underreporting and Surveillance Challenges 37
Public Health Implications 38
EVOLVING UNDERSTANDING AND LONG-TERM CONSEQUENCES 40
Traditional Views Versus Modern Research 40
Risks of Prolonged and Repeated Injury 41
Post-Concussion Syndrome 43
Cognitive Decline and Repeated Concussions 47
SYMPTOMATOLOGY AND CLASSIFICATION 48
Classification by Severity 48
Mild Traumatic Brain Injury /Concussion 49
Moderate to Severe TBI 53
Severe Traumatic Brain Injury 54
Classification by Mechanism of Injury 55
Classification by Anatomical Distribution 57
Classification by Clinical Course 60
Classification of Concussion 61
Sport-Related Concussion Grading 62
Pediatric Concussion Considerations 62
Temporal Classification 63
Acute Phase 63
Subacute Phase 63
Chronic Phase 63
Imaging-Based Classification 64
Computed Tomography Classification 64
Advanced Neuroimaging Classification 64
Outcome-Based Classification 65
Glasgow Outcome Scale 65
Functional Independence Measure 65
Complications and Secondary Injury Classification 66
Post-Traumatic Epilepsy 66
Post-Concussion Syndrome 67
Emerging Classification Approaches 67
Biomarker-Based Classification 67
Machine Learning and Artificial Intelligence 67
Concussion-Specific Considerations 68
Neurological Basis of Symptoms 69
Importance of Early Recognition and Monitoring 70
DIAGNOSIS OF CONCUSSION AND MILD TRAUMATIC BRAIN INJURY 71
Clinical Evaluation 71
Standardized Assessment Tools 73
Neuroimaging and Advanced Diagnostics 74
Biomarkers and Laboratory Testing 77
Special Populations 79
CHAPTER II: THERAPIES AND MANAGEMENT: CONVENTIONAL APPROACHES 81
Acute Medical Management 83
Emergency and Critical Care 83
Surgical Interventions 84
Medical Management of Intracranial Pressure 85
Pharmacological Interventions. 85
Neuroprotective Agents 85
Symptomatic Management 87
Pain Management 88
BIOLOGICAL INSIGHTS IN CONCUSSION: NEUROBIOLOGICAL MECHANISMS AND MANAGEMENT 89
Neuroanatomical Organization and Cellular Heterogeneity 91
Molecular Pathophysiology of Concussive Injury 95
Cellular and Molecular Mechanisms of Cognitive Dysfunction 110
Synaptic Pathophysiology 110
Large-Scale Network Alterations 114
Advanced Neuroprotective and Regenerative Strategies 115
Neuropeptide-Based Approaches 115
Mito-organells CNS Brain 119
Cellular Replacement and Regeneration 123
Neural Precursor Stem Cells 132
Frontal Lobe Neural Precursor Stem Cells 157
Temporal Lobe Neural Precursor Stem Cells 158
Parietal Lobe Neural Precursor Stem Cells 161
Occipital Lobe Neural Precursor Stem Cells 162
Mesenchymal Stem Cell 163
Exosomes- Extracellular Vesicle Approach 165
Plaqx – the cellular support 169
CHAPTER III: PHYSIOTHERAPY IN CONCUSSION 175
Hyperbaric Oxygen Therapy (HBOT) 175
Ozone oxygen therapy 179
Transcranial direct current stimulation (tDCS) 183
Morphogenetic Harmonizer System, Scalar Plasma Wave Modulator 187
Precision Medicine and Biomarker-Guided Therapy 189
Advanced Proteomic Biomarkers 189
Genomic and Epigenetic Factors 189
Epigenetic Modifications and Therapeutic Targets 190
Rehabilitation Services 191
Physical Therapy 191
Occupational Therapy 192
Speech-Language Pathology 193
Neuropsychology 194
Psychological and Psychiatric Support 195
Mental Health Assessment and Treatment 195
Psychopharmacological Management 196
Long-Term Care and Support 197
Case Management and Coordination 197
Community Integration Programs 198
Family Education and Support 199
Quality of Life and Outcome Measurement 199
Functional Assessment 199
Long-Term Monitoring 201
Challenges and Limitations of Conventional Approaches 201
Access and Availability Issues 201
Individual Variability in Response 202
Economic Considerations 203
THE TICKING TIME BOMB: FROM DENIAL TO A PATH FORWARD 205
BIBLIOGRAPHY 211

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