Publications

Inside these pages, you’ll discover:

• Clinically documented remarkable improvements in neurodevelopmental disorders, recoveries from liver and kidney failure, stroke, Parkinson’s, heart failure, and beyond.
• Emerging protocols combining stem cells with bioactive molecules and exosomes — protocols shaping tomorrow’s care.
• Practical insights into safety, delivery routes, and outcome metrics.
• A critical view on current limitations, future potential, and medical responsibility.
• Pathways to healing: clinical strategies and cellular intelligence - from stem cell origins to measurable recovery in real-world medicine.

Stem Cells: The Untold invites you to look beyond the headlines—and into the evidence-based exploration of stem cell therapeutics as they transition from investigational to clinical application. From hypothesis to healing—this book captures the translational arc of stem cell medicine in contemporary practice.

Not merely a sequel to Stem Cells in Regenerative Medicine: Carpe Diem, Carpe Vitam!, but a new genesis — Stem Cells: The Untold captures the extraordinary clinical evolution and scientific breakthroughs that have redefined regenerative medicine in less than a decade.

Prof. Dr. Dmytro Klokol MD, PhD
Anti-aging and regenerative medicine and surgery expert. Head of Medical Advisory, European Wellness Biomedical Group — Main author and editor-in-chief.

Prof. Dr. Mike K.S. Chan
Founder & Chairman of the European Wellness Biomedical Group, Head of Scientific Commitee for Regenerative Medicine & Asian Chairman — ESAAM (European Society of Preventive, Regenerative & Anti-Aging Medicine).

Authors: Prof. Dr. Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Dr. Dmytro Klokol, Florisa Landa, Nur Shafawati Saili, Siti Azmah Jambo, Brenda Song Pei Chui, Raz Haziqah Hani Razali, Max Michael Samson, Aziera Farhanah Adihidayah Suardi, Fiona Macniesia Thomas, Chin Mei Ling, Krista Casazza, Isso Kimura, Mohd Iskandar Jumat and Prof. Dr. Michelle B.F. Wong
Publisher: Advances in Clinical and Medical Research; 6(2), 2025
Publisher's URL: https://www.genesispub.org/mapping-human-organ-aging-from-cellular-mechanism-to-clinical-applications-for-precision-medicine-in-healthspan-to-lifespan

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Memory is a fundamental cognitive function that enables individuals to absorb, retain, and utilize information acquired through experience. It shapes knowledge, skills, and abilities, interacting dynamically with individuals’ mental and personal attributes. This bidirectional relationship means that while memory depends on accumulated experiences and learning, it also contributes to their continuous development. Cognitive impairment, often called an intellectual or learning disability, includes limitations in mental processing, social interactions, communication, and self-sufficiency.

This book explores the intricate nature of memory and its role in overall cognitive health and potential interventions for memory decline. The discussion extends beyond conventional medical approaches, including integrative and innovative solutions that bridge traditional wisdom with modern scientific advancements.

Enhancing Memory: Integrative Approaches with Innovative Solutions to BrainSpan in Longevity & Regenerative Medicine focuses on a holistic approach to memory enhancement, combining neuroscience, regenerative medicine, and alternative therapies. The book integrates time-tested traditional remedies with cutting-edge biological research, providing a comprehensive perspective on improving and maintaining memory function. Including original biological products further underscores the synergy between scientific progress and practical applications in cognitive health management. Whether dealing with mild memory lapses, seeking preventive measures, or managing more complex neurological conditions, readers will find practical and evidence-based guidance to support brain longevity and overall mental well-being.

Ultimately, this book serves as both an educational resource and a practical guide for anyone interested in understanding the science behind memory preservation and cognitive enhancement. It emphasizes that with early detection, proactive intervention, and continuous research, individuals can take meaningful steps toward maintaining cognitive vitality throughout life.

Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.

Dr Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.

Obesity and Metabolic Syndrome: Bioregenerative Medicine with Stem Cell Therapy is a comprehensive book covering the basic scientific facts about the metabolic disorders. It contains the modern concepts of the occurrence, development, and course of obesity, metabolic syndrome, and its complications, e.g., type 2 diabetes mellitus and cardiovascular disorders. Grounded in the recent findings of clinical and laboratory studies, the authors reveal the principal causes of the complications of the metabolic disorders and propose structural approaches to the treatment and prevention of its progression.

Featuring modern concepts of the treatment of obese, diabetic and metabolic syndrome patients, the book includes interventions such as lifestyle changes, dietary approaches, evidence-based pharmacology, and bioregenerative medicine. Demonstrating the weak links in the pathogenesis of these metabolic disorders and their complications, the authors present the scientifically proven recommendations for preventive and restorative measures. Combining deep science with current practice, this book contains easy-to-use recommendations regarding diet, physical activities, medicinal options, and bioregenerative potential to cure metabolic disorders. Narrow and deep review as well as the authors combined medical and research experience will be of value to persons with diabetes and metabolic syndrome, their physicians, and all who has interest in regenerative and antiaging medicine.

Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of cellular and cell membrane therapy in Europe and Asia since the early 1980s. He founded one of the world’s largest researchers of bio-molecular medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.

Dr. Yuriy Nalapko, MD, PhD, is an academician and practical medical doctor in intensive care, antiaging, and bioregenerative medicine—an area of scientific interest in longevity and how a cell functions with different diseases. He is the author of many handbooks, monographs, and more than 300 articles. Based on his clinical experience, he proposed new approaches to reverse degenerative diseases of the brain, liver, and endocrine organs in different disorders. In metabolic disorder therapy, he combines preventive, pharmacological, and bioregenerative approaches as a state-of-the-art paradigm to correct structural and functional malfunctions.

Dr. Svetlana Yartseva, MD, PhD, is a certified endocrinologist and internal diseases practitioner. A member of several international associations on the study of diabetes, such as the European Thyroid Association and the European Association of Preventive, Regenerative, and Antiaging Medicine, she is a consultant at numerous private clinics. Her main concern is treatment of patients with obesity, metabolic syndrome, and diabetes mellitus through modern pharmacological and non-pharmacological methods.

Autologous Antigen-Specific Immunotherapy (AASI) is redefining how we treat autoimmune and immune-mediated diseases, from Type 1 diabetes and multiple sclerosis to allergies, organ transplantation, and even cancer.

In this comprehensive new article, discover how AASI leverages a patient’s own immune cells to restore immune tolerance with precision, safety, and potential applications across diverse clinical fields.

🔬 Key Highlights:

✔️ Explains how AASI targets disease-causing antigens while preserving normal immunity
✔️ Showcases cutting-edge AASI platforms: tolerogenic dendritic cells (tolDCs), nanoparticles, peptide conjugates, and CAR-Tregs
✔️ Explores clinical potential for autoimmune diseases (T1D, MS, SLE, RA), allergies, transplant rejection, and cancer
✔️ Highlights challenges and future directions in biomarker profiling, AI-guided antigen selection, and personalized delivery systems
✔️ Emphasizes safety and selectivity as the next frontier in immune tolerance therapy

This review calls for a shift from immunosuppression to immune education toward a future of targeted, lasting, and safer interventions.

🧬 AASI isn’t just a treatment. It’s a paradigm shift in immunotherapy.

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A new scientific review just published in the American Journal of Biomedical Science & Research explores a fresh approach to managing Crohn’s Disease – by focusing on restoring immune balance and repairing gut integrity from the inside out.

Led by experts from European Wellness – including Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, and Prof. Dr. Dmytro Klokol – alongside collaborators from UC Irvine and GATC Health Inc, this review lays the foundation for a more targeted, potentially more holistic path forward in this field.

What their research helped uncover:
🔹 Advanced cell-based approaches, like organoid and stem cell therapies, may help rebuild damaged gut lining
🔹 Peptide-powered strategies may reduce inflammation, support healing, and bring precision to immune regulation
🔹 Tolerogenic immune training – an approach that could potentially teach the immune system to stop overreacting without suppressing it entirely
🔹 A combined framework that aims to go beyond symptoms by addressing root imbalances

Research is still in early stages – but the possibilities are definitely worth exploring. This research could signal a promising shift for patients living with IBD worldwide.

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💡 About the Article:

Alzheimer’s Disease (AD) is a complex neurodegenerative disorder with no known cure. This comprehensive review presents a holistic, multi-pronged strategy that goes beyond conventional treatments—integrating cutting-edge approaches from regenerative medicine, cellular therapy, and personalized lifestyle interventions.

📌 Key Highlights:

✔️ The article explores the roles of neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic failure in AD pathology
✔️ It introduces the potential of peptide therapy, nano-organo preparations, and cell therapy to modulate neurodegeneration and promote neuroregeneration
✔️ Emphasis on the gut-brain axis, blood-brain barrier integrity, and immune modulation as therapeutic targets
✔️ Advocates for an integrative care model—blending science-based interventions with functional, metabolic, and lifestyle medicine for optimal brain health and quality of life

🔬 This paper charts a forward-looking path for managing AD with precision tools that address root causes—not just symptoms—of cognitive decline.

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Authored by an international team that includes European Wellness experts Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, Prof. Dr. Dmytro Klokol and Prof. Dr. Olha Nishkumai alongside researchers from the University of California, Irvine (UCI), the study explores advanced peptide therapeutics that specifically target mitochondrial dysfunction, fibrosis, and inflammation – 3 critical factors in cardiac disease.

Here’s why this research is exciting…
🔹 Peptides can be engineered to reach specific cells and organelles in the heart, potentially reducing side effects compared to traditional treatments.
🔹 Preclinical trials show potential in repairing damaged heart tissue, reducing inflammation, and improving cardiac function.
🔹 Novel peptide systems like NOPs (nano-organo peptides) and MTPs (mitochondria-targeted peptides) may help fine-tune treatment like never before.

Research continues – but this could be a major step toward a new kind of precision therapy for one of the world’s biggest health challenges! 💡

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💡 What’s Inside?

While traditionally known for energy production, mitochondria are now recognized as master regulators of wellness—influencing everything from neurodegeneration and immune health to metabolic balance and aging.

This article explores how Mitochondrial Organelle (MO) Therapy, using peptide formulations like MF-Plus, is revolutionizing regenerative medicine by restoring mitochondrial function and reversing cellular decline.

📌 Key Highlights:

✔️ Mitochondria regulate ATP production, calcium homeostasis, redox signaling, and apoptosis prevention
✔️ MO peptides and mitochondrial-derived vesicles (MDVs) support regeneration, anti-aging, and disease recovery
✔️ Evidence of efficacy in neurodegenerative, cardiovascular, metabolic, and dermatological conditions
✔️ Routes of administration include intramuscular, intravenous, and mesotherapy, shown to support both aesthetic and clinical benefits
✔️ Potential applications in stroke recovery, ischemia, fatty liver disease, and cellular rejuvenation

🔬 This article sheds light on mitochondria’s central role in orchestrating biological repair and how mitochondrial transfer and MO-based therapies may soon become the cornerstone of precision regenerative medicine.

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💡 About the Article:
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with no FDA-approved treatments targeting its core biological mechanisms. This review explores the promising role of therapeutic peptides in modulating the underlying neurobiology of ASD.

📌 Key Highlights:

✔️ Peptides can cross the blood-brain barrier and target neuroinflammation, synaptic plasticity, and mitochondrial dysfunction
✔️ Mitochondria-derived peptides (MDPs) like Humanin, MOTS-c, and SHLP2 enhance neuronal survival, reduce oxidative stress, and modulate immune responses
✔️ Nano Organo Peptides (NOPs) and Mitochondrial Organelle (MO) Peptides represent next-gen therapies for metabolic restoration, neuroimmune modulation, and synaptic repair
✔️ Clinical studies on peptides like Oxytocin, VIP, Melatonin show early promise in improving social behaviors, sleep, and reducing neuroinflammation in ASD
✔️ Peptide therapies may bridge neurobiology with precision therapeutics, offering a path toward true disease-modifying interventions for ASD

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