Acute Toxicity Assessment of PO Retina Following a Single Subcutaneous Administration in Male Albino Rats

Science moves one careful step at a time… and this is an important early one! In a new preclinical study on Research Square, European Wellness researchers and international collaborators assessed the acute safety of PO Retina – an investigational peptide-based formulation developed for retinal applications.

Here’s what they found: Following OECD Guideline 423 – the international standard for acute toxicity testing – rats received a single high dose (2000 mg/kg) of PO Retina, then were closely observed for 14 days:

✅ No mortality, morbidity, or abnormal clinical signs in any animal

✅ Normal body weight gain, feed intake, and water consumption throughout

✅ Organ weights – including the retina – comparable to controls

💡 Why this matters: Before any formulation can be studied for what it might do, researchers must first show it is well tolerated. These results support PO Retina’s preliminary acute safety profile at the tested dose – with repeated-dose, histopathology, and ocular functional studies recommended as the next steps.

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