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Peptides 101 – Regenerative Applications in Modern Medicine

Price range: $63.00 through $150.00

Peptides 101: Regenerative Applications in Modern Medicine provides a foundational overview of peptide biology and their expanding therapeutic roles in regenerative and functional medicine. The book reviews peptide structure, synthesis, and signaling pathways, with emphasis on their applications in tissue repair, immune modulation, neuroprotection, and metabolic regulation. Integrating current research with clinical perspectives, it highlights safety profiles, evidence-based protocols, and emerging trends in peptide therapeutics. Designed for clinicians, biomedical researchers, and students, this text bridges basic science and translational medicine to illuminate the regenerative potential of peptide-based interventions.

Unlock the therapeutic power of peptides—nature’s own precision messengers—in this comprehensive introduction to their role in regenerative and integrative medicine. From cellular signaling and tissue repair to neuroprotection and metabolic optimization, Peptides 101 demystifies complex biochemical pathways and translates cutting-edge science into practical medical insight.

Inside, you’ll explore:

  • Core principles of peptide biology and receptor signaling; Clinical applications in reversal of chronic diseases and metabolic syndrome, wound healing, longevity and neuroregeneration;
  • Evidence-based discussion of safety, dosing, and protocols;
  • Future directions in peptide-based therapeutics and personalized medicine.
  • Whether you’re a physician, researcher, or student of modern bioregenerative science, this book provides the foundation and framework to understand and apply peptide therapy responsibly and effectively.
$125.00
$63.00
$150.00
SKU: 9781662971921 Categories: ,

Description

Authors

Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Olha Nishkumai and Dmytro Klokol

Published by

EUROPEAN WELLNESS ACADEMY – Medical Research

ISBN: 9781662971921

eISBN: 9781662971938

DOI: https://doi.org/10.69669/vj2793

Author Bio:

Mike K.S. Chan, Researcher, Author, and Educator, Founder and Chairman of the European Wellness Biomedical Group; Senior Technical Consultant at EWBG; Head of Scientific committee of preventive, regenerative and anti-aging medicine and Asian Chairman (ESAAM); Adjunct Professor of Lincoln University College (Malaysia); Associate Professor of AASCP, USA (American Academy of Stem Cell Physicians), Chairman for A4M, USA (American Academy of Anti-Aging Medicine) for Thailand/Asia, Japan’s Regenerative Medical Association MMJ (Multi-Dimensional Holistic Medical Team Japan) and co-Founder of FCTI Precursor Stem Cells (Europe), Author of over 70 books and over 150 publications, has experience of 45 over years in Stem cells Research in Germany, Switzerland, European Union, Soviets, China, Mexico, USA, Japan, Middle East since early 80’s, presenter for over 10000 presentations and scientific lectures globally at most major conferences of the World on anti-aging and precision medicine. He is also a pioneer in Regenerative Medicine and Cellular Therapies in a big way in the 80’s into Asia Pacific, the Middle East and Australia.

Thomas Skutella, MD, PostDoc (Max Planck Institute for Psychiatry, Munich, Germany), Full Professor at Heidelberg University, former group leader in the Neuroscience Research Center (Charite Berlin, Germany), director of the Center for Regenerative Medicine (Tübingen, Germany), Head of the department of Neuroanatomy in the Institute for Anatomy and Cell Biology (Heidelberg, Germany), Group for Regeneration and Reprogramming, Medical Faculty, Institute for Anatomy and Cell Biology, Heidelberg University (Germany).

Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D. (University of Alberta at Edmonton, Canada), Professor Emeritus, Department of Surgery, University of California Irvine (CA, USA); Department of Biomedical Engineering, University of California Irvine (CA, USA), Director of Research at the Clinical Islet Program in the Department of Surgery at the University of California, Irvine (CA, USA), Outstanding Leadership in Alberta Science Award from the Alberta Science and Technology Leadership Foundation, the Outstanding Achievement Award from the Canadian Diabetes Association, and Royal College of Physicians and Surgeons.

Olha Nishkumai, MD, PhD, Professor, Doctor of Medical Sciences, Board Certified Specialist Cardiologist, Rheumatologist, and Internal Medicine specialist; Full Professor at the Department of Internal Medicine No. 2 at Bogomolets National Medical University (UA); Medical Consultant at the European Wellness Biomedical Group.

Dmytro Klokol, MD, Specialist in General Surgery (Board Certified, MoH UA), PhD (Emergency and Reconstructive Surgery), GCP (Malaysia, USA), PostDoc (Regenerative Medicine, NL, EU); Certified expert in Interventional procedures in Regenerative Medicine and chronic pain management (Spain, EU); Certified Educator at International Accreditation Organization (IAO, USA); HRDCorp certified educator and trainer (Malaysia); International Board for Anti-aging and Regenerative Medicine (IBARM, USA) certifying academic board member.

Table of Content

LIST OF ABBREVIATIONS X111
ABOUT THE AUTHORS XXVII
INSTEAD OF PROLOGUE: THE MOLECULES OF RETURN 1
CHAPTER 1 THE MOLECULAR RENAISSANCE: PEPTIDES AS PIONEERS IN REGENERATIVE MEDICINE 7
From Molecular Fragments to Therapeutic Frontiers 7
Peptides: The Forgotten Molecules Reborn 8
Mechanisms of Action: Beyond Signaling 9
Nanomization: A Paradigm Shift in Peptide Stability and Bioavailability 14
Xenogeneic and Organo-Specific Peptides: Rewriting the Source Code 16
Mitochondria-Targeted Peptides: A New Axis in Regenerative Therapeutics 17
Senescence, Inflammation, and the Aging Microenvironment 18
From Bench to Bedside: Preclinical and Translational Evidence 24
Toward a Peptide-Based Regenerative Paradigm 25
Organelle-Specific Peptides: Mitochondria as Master Regulators of Regeneration 26
Clinical Outlook of MO Peptide Therapy 29
Integration with Other Regenerative Modalities 32
Reimagining Regeneration Through Peptides 35
CHAPTER 2 THE HISTORY OF PEPTIDE THERAPY: FROM INSULIN TO ORGAN‑SPECIFIC BIOACTIVE FORMULATIONS 39
Prologue: A Century of Peptide Vision 39
The Dawn: Insulin and the Peptide Revolution 40
Organ Extracts and the Swiss/German Tradition of Tissue Therapy 45
Paul Niehans and the Era of Live Cell Therapy 45
Thymus Peptides: From Immune Modulation to Regenerative Application 49
Peptide Chemistry, Technology, and the Expansion Era 51
Mitochondrial Peptides: From Hidden Genomic Messages to Therapeutic Agents 52
The Rise of Nano‑Organic Xenogeneic Peptides 53
Interpreting the Arc: Patterns, Lessons, and Legacy 57
Epilogue: From Legacy to Frontiers 58
CHAPTER 3 SAFETY, CARCINOGENICITY, AND CHARACTERIZATION OF THERAPEUTIC PEPTIDES (with Prof. Thomas Skutella, MD, PostDoc) 59
Why Safety Matters in Peptide Therapeutics 59
MTT and Cell Transformation Assays of Mito Organelles Extracts 60
Molecular Fingerprinting and Quality Control 66
Conclusion: Confidence Through Rigor, Humility Before Complexity 72
CHAPTER 4 PEPTIDES IN CARDIOLOGY: MITOCHONDRIAL, NANO‑PEPTIDE, AND ORGAN‑SPECIFIC STRATEGIES (with Prof. Dr. Olha Nishkumai, MD, PhD) 75
Introduction: The Heart’s Peptide Frontier 75
Mitochondria in the Heart: Vulnerabilities and Therapeutic Windows 76
Nano‑Peptides, Organ-Specific Delivery and Mito Organelles in Cardiology 80
Organ-Specific Peptide Strategies and Mito Organelles 81
Case Studies and Emerging Evidence in Peptide‑Based Cardiac and Vascular Protection 83
Challenges, Unanswered Questions, and Future Directions in Cardiovascular Peptide Therapy 86
Conclusion 87
CHAPTER 5 PEPTIDES AS REGULATORS IN THE PATHOPHYSIOLOGY AND TREATMENT OF METABOLIC SYNDROME (with Prof. Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D) 89
The Peptide Network Underlying Metabolic Homeostasis 90
Mitochondrial Dysfunction and the Emergence of Mitochondrial Peptides 93
Aging, Klotho, and the Peptidic Interface of Metabolism 95
Nanomized Organ-Specific Peptides (NOPs) and Peptide Delivery Principles 96
Incretin Peptides, Dual/Triple Agonists, and Peptide Synergy 97
Peptide modulation of metabolic pathways: Mechanisms in Metabolic Syndrome 99
Clinical Indications, Patient Selection, and Therapeutic Goals 104
Protocols for Mitochondrial Peptides 106
Protocols for Klotho-Derived Peptide Fragments 110
Protocols for Nanomized Organ-Specific Peptides (NOPs) and Mito Organelles (MOs) Organ-specific Peptides (OSPs) 111
Protocols for GLP‑1 / Incretin / Multi-agonist Peptides in Metabolic Syndrome 112
Combining GLP‑1 Agonists with Mitochondrial or Klotho Peptide Therapy 113
Conclusion 116
CHAPTER 6 PEPTIDE THERAPEUTICS FOR RETINA AND OPTIC NERVE—MODULATING IMMUNITY, REGENERATION & NEUROPROTECTION 119
Pathobiology of Retinal Degeneration and Optic Neuropathy—the Rationale for Peptide Interventions 120
Bioactive Peptides in the Retina—Mechanisms of Action 122
Integration with Stem/Progenitor Cell Therapies in Glaucoma 126
CHAPTER 7 PEPTIDES IN NEURODEGENERATIVE DISORDERS— REGENERATION, PLASTICITY, AND DISEASE MODIFICATION 131
The Landscape of Neurodegeneration: Common Pathways and Therapeutic Niches 132
Parkinson’s and Synucleinopathies: Targeting α‑Synuclein with Peptides 135
Peptide-Based Treatment Protocols: Clinical Approaches with Mito Organelles and Regenerative Peptides 139
Application of Mito Organelles Peptide Therapy in Stroke Recovery 143
CHAPTER 8 PEPTIDES AS THERAPEUTIC MODALITIES IN GASTROINTESTINAL DISORDERS 149
Pathophysiology: Leaky Gut, Crohn’s Disease, and Colitis 151
Proposed Peptide Protocols and Expected Outcomes 158
CHAPTER 9 PEPTIDE-BASED STRATEGIES FOR CARTILAGE REGENERATION IN OSTEOARTHRITIS: MITOCHONDRIAL THERAPEUTICS AND MITO ORGANELLES INTEGRATION (with Prof. Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D.) 163
Mitochondrial Dysfunction in Cartilage Degeneration 165
Mito Organelles Cartilage and Placenta: A Novel Bioactive Paradigm 170
Other Peptide Therapeutics in Cartilage Restoration 170
CHAPTER 10 THYMIC PEPTIDES AND THYMUS EXTRACTS IN REGENERATIVE AND PEPTIDE-BASED MEDICINE (with Prof. Thomas Skutella, MD, PostDoc) 175
Historical Foundations and Scientific Rationale 175
Mechanisms of Action and Immunological Implications 176
Mitochondrial Thymic Peptides: Origin and Function 180
Regenerative and Anti-Aging Medicine: Immunosenescence and Thymic Rejuvenation 185
Clinical Protocols in Thymic Peptide Therapy 187
CHAPTER 11 PEPTIDES IN AESTHETIC DERMATOLOGY 195
Skin aging, dermal matrix degradation and the theoretical basis for peptides 197
Injectable peptide therapies and mesotherapy in aesthetic dermatology 200
Restoration of eyelashes and eyebrows in aesthetic dermatology 213
CHAPTER 12 HUMAN GROWTH HORMONE: DISCOVERY, SYNTHESIS, PHYSIOLOGY, AND CLINICAL APPLICATIONS IN REGENERATIVE MEDICINE (with Dr. Dmytro Klokol, MD, PhD) 221
Historical Discovery and Biotechnological Synthesis 221
Physiology: Regulation, Receptor, and Mechanism of Action 222
Mechanisms Relevant to Regenerative Medicine and Anti-Aging 223
Evidence and Clinical Applications 224
Risks, Adverse Effects, and Limitations 225
Evidence-Based Medical Data: What Is Well Established, What Is Tentative 226
Practical & Ethical Considerations and Future Directions 226
Human Growth Hormone in Anti‑Aging & Regenerative Medicine: Clinical Trials & Peptide‑Therapy Protocols 227
Clinical / Peptide Therapy Protocols: GH, GH Secretagogues, Combination Approaches 229
THE LAST CHAPTER OF THIS BOOK: PEPTIDES IN BODY BUILDING AND ATHLETIC BODY RECOMPOSITION (by Dr. Dmytro Klokol, MD, PhD) 237
Mechanisms of Action: Understanding What Peptides Do 238
Key Peptides: Anabolic, Regenerative, and Lipolytic Agents 240
Phased Use of Peptides in Bodybuilding 241
Side Effects and Risk Management 245
Insulin Use in Bodybuilding—Mechanisms, Applications, and Scientific Basis 245
Personal Perspective: Peptides at the Frontlines of Performance, Recovery, and Reinvention 249
REFERENCES 253

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