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Proactive Ageing: Comprehensive Strategies for Muscle Preservation & Sarcopenia Resistance in Bioregenerative Medicine

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Proactive Ageing: Comprehensive Strategies for Muscle Preservation and Sarcopenia Resistance is an essential guide which reveals the hidden epidemic of sarcopenia, the silent muscle-wasting condition that affects millions as they age. With a deep dive into the root causes—hormonal imbalances, chronic inflammation, and lifestyle choices—this book arms you with the knowledge to detect and prevent muscle loss before it takes its toll.

Readers will explore the cutting-edge world of regenerative medicine which offers breakthrough therapies like peptide treatments and mitochondria-specific interventions offer new hope for reversing muscle decline. Whether you’re a healthcare professional or someone determined to stay strong and active as the years go by, this book offers a comprehensive, science-backed roadmap to maintaining muscle health, preventing age-related diseases, and living a vibrant, long life.

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SKU: 9781662963834 Categories: ,

Description

Authors

Prof. Dr. Mike K.S. Chan and Dr. Simon Yefimov

Published by

EUROPEAN WELLNESS ACADEMY – Medical Research

ISBN: 9781662963834

eISBN: 9781662963841

Library of Congress Control Number: 2025936178

DOI: https://doi.org/10.69669/uq7049

Author Bio:

Prof. Dato’ Sri Dr. Mike K.S. Chan is Founder & Chairman of the European Wellness Biomedical Group and Chief Researcher/Chief Technical & Research Director across its international R&D programs. A pioneer of cellular therapy since the 1980s, he helped introduce stem cell and bioregenerative medicine across Asia, building a global network of clinics and research centers—today a chain of 40+ integrative and regenerative medical clinics with 1,000+ staff. He serves as ESAAM Scientific Committee Head for Regenerative Medicine & Stem Cells and ESAAM Chairman/Director for Asia; Associate Professor (AASCP, USA); Associate Professor (Lincoln University College, Kuala Lumpur); Chairman of the European Wellness Academy; Senator of Germany’s BWA; and Honorary Chief Healthcare Advisor to Swiss Strategic Partners. His portfolio includes multiple international patents in immunotherapy, stem cell transport media, and parenteral formulations, and he is a multi-award recipient in Europe and the Middle East. An active academic collaborator (MIT, Cambridge, USC, UCI, Heidelberg), Prof. Chan has authored/co-authored 60+ books and 140+ scientific publications, and has delivered 1000+ lectures and seminars across 60+ regions on anti-aging, regenerative medicine, peptides, and stem cell therapies..

Dr. Simon Yefimov MD earned his medical degree from Luhansk State Medical University (2006–2012). During his academic journey, he was an active member of the Academic Community Mental Health and received recognition for his contributions. Notably, he won a prize at the Mental Health national academic competition in 2010. His qualifications include a radiology specialist degree from Luhansk State Hospital (2012–2014) and a radiological investigations medical specialist degree (2013–2014). Dr. Yefimov further honed his skills through practical courses, including ultrasound research at Luhansk Regional Oncologic Dispensary and contrast-enhanced radiological studies at Luhansk State Hospital. Professionally, Dr. Yefimov served as a radiologist at Luhansk Municipal Hospital Number 4 (2014–2015) before joining the Diagnostic and Treatment Centre “Meddiagnostika” in Kiev, where he continues to practice as a radiologist. Additionally, he has been actively involved in Cell Therapy, Biological, Integrative & Regenerative Medicine in Europe since 2016. Dr. Yefimov’s research interests led him to co-author an article titled “CELL THERAPY AS THE MAIN STRATAGEM OF ANTI-AGING AND REGENERATIVE MEDICINE,” published in the European Journal of Pharmaceutical And Medical Research (2019, 6(6), 295–299). His technical expertise encompasses fixed radiography systems (both digital and analog), mobile x-ray systems, and ultrasound systems.

Table of Content

PART 1: Introduction to Sarcopenia within the Proactive Ageing Framework

CHAPTER 1: SARCOPENIA: UNVEILING THE HIDDEN EPIDEMIC IN AGING 3
Understanding Sarcopenia: A Comprehensive Overview 4
Environmental Influences on Sarcopenia: Urban vs. Rural Dynamics 5
The Psychological Dimensions of Sarcopenia: Beyond Physical Decline 6
CHAPTER 2: ETIOLOGICAL FACTORS CONTRIBUTING TO SARCOPENIA 9
Hormonal Dysregulation and Its Role in Muscle Loss 9
Chronic Inflammation: The Inflammaging Connection 12
Oxidative Distress: Agitating Muscle Degradation 13
Nutritional Deficiencies and Anabolic Resistance 15
Physical Inactivity: The Silent Catalyst of Muscle Deterioration 17
Aging and the Brain: Central Nervous System’s Influence on Muscle Performance 19
Neuromuscular Alterations and Their Impact on Muscle Function 20
CHAPTER 3: RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH SARCOPENIA 21
Obesity and Sarcopenia: The Double Burden 21
Unhealthy Lifestyle Choices: Diet, Alcohol, and Smoking 24
Chronic Disease Interactions: Diabetes, Cardiovascular Diseases, and CKD 27
Epigenetic Modifications and Their Role in Muscle Health 30
CHAPTER 4: DIAGNOSTIC APPROACHES IN SARCOPENIA ASSESSMENT 31
Clinical Manifestations: Identifying Signs and Symptoms 31
Comprehensive Assessment Strategies for Sarcopenia 34
Advanced Tools for Sarcopenia Early Detection and Monitoring 44

PART 2: Proactive Prevention Strategies for Sarcopenia Resistance

CHAPTER 5: NUTRITIONAL AND LIFESTYLE INTERVENTIONS FOR SARCOPENIA PREVENTION 51
Adequate Protein Consumption: The Foundation of Muscle Preservation 52
Combating Inflammation and Oxidative Stress with Diet 53
Evolutionary Perspective on Diet: Aligning Modern Eating Habits with Ancestral Patterns 54
The Mediterranean Diet: A Model for Healthy Ageing 55
The Role of Intermittent Fasting 58
Importance of Proper Hydration 59
Proper Physical Activities and Exercises 60
The Importance of Social Interactions and Support Networks 61
Mental Health and Clarity 62
Sleep and Recovery 63
Regular Health Screenings and Their Importance 65
Technology and Innovation in Health Monitoring 65
Avoiding Sedentary Behavior, Smoking, and Alcohol Consumption 66
CHAPTER 6: ESSENTIAL VITAMINS AND MICRONUTRIENTS IN MUSCLE PRESERVATION 69
Vitamin D, Magnesium, and Calcium: The Bone-Muscle Connection 70
The Role of Antioxidants in Muscle Function: Vitamin C, E, CoQ10, and Omega-3 Fatty Acids 77
Amino Acids and Muscle Anabolism: Branched-Chain Amino Acids (BCAAs) and Creatine 85
B Vitamins and Cellular Metabolism 88
Critical Micronutrients for Muscle Preservation: Zinc, Iron, Selenium, and Potassium 93
Advanced Bioactive Compounds in Muscle Preservation: NAD+ (Nicotinamide Adenine Dinucleotide) and Its Precursors 99

PART 3: Advanced Regenerative Medicine Approaches in Sarcopenia Management

CHAPTER 7: ADDRESSING INFLAMMAGING THROUGH REGENERATIVE MEDICINE 105
The Limitations of Diet Alone in Inflammaging Management 105
Herbal Extracts: The Synergistic Potential of Resveratrol, Apigenin, and Kaempferol 108
Cytokine Inhibitors: A Targeted Approach to Managing Chronic Inflammation 113
The Therapeutic Potential of JAK Inhibitors in Sarcopenia Management 115
Senolytics: Targeting Senescent Cells to Combat Chronic Inflammation 116
CHAPTER 8: PEPTIDE THERAPIES: PIONEERING MUSCLE REGENERATION 119
BPC-157 and Thymosin Beta 4: Their Roles in Tissue Repair 119
TB-500, IGF-1, and GHRP-6: Enhancing Muscle Anabolism 120
Follistatin: Overcoming Myostatin Inhibition for Muscle Growth 123
CHAPTER 9: MITOCHONDRIA-SPECIFIC PEPTIDES: REJUVENATING CELLULAR FUNCTION 125
Transitioning from Mono-Peptides to Mitochondria-Targeted Therapies 125
Mitochondrial Peptides in Sarcopenia: Therapeutic Mechanisms 127
Bio-Hormonal Rejuvenation: Enhancing Longevity through Mitochondrial Health 129
Mitigating Age-Related Supraspinal Changes through Mitochondria-Organ Peptides 130
Immune System Decline Management through Thymus Regeneration 132
CHAPTER 10: COMPREHENSIVE MANAGEMENT OF COMORBIDITIES IN SARCOPENIA 137
Addressing Metabolic Syndrome and Diabetes Mellitus through Regenerative Medicine 137
Cardiovascular Health: Integrating Peptides and Stem Cells in Treatment 138
Addressing Chronic Kidney Disease (CKD) with Peptideand Cell-Based Therapies 140
CLOSING THOUGHTS 145
BIBLIOGRAPHY 147

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