Publications

💡 About the Publication:

This powerful review explores how mesenchymal stem cells (MSCs) and neural stem/progenitor cells (NSPCs) offer transformative potential in the treatment of complex neurodegenerative and neuroinflammatory diseases such as Alzheimer’s, Parkinson’s, ALS, MS, stroke, TBI, and SCI.

These two stem cell types are uniquely positioned to:

✔️ Address key pathologies like neuronal loss, inflammation, and blood-brain barrier (BBB) dysfunction
✔️ Promote cell replacement, neuroprotection, synaptic plasticity, and remyelination
✔️ Deliver therapeutic effects through direct regeneration and powerful paracrine signaling
✔️ Reduce oxidative stress and neuroinflammation, while enhancing recovery through trophic and immunomodulatory actions

With insights from clinical and preclinical models, the article also compares the unique advantages and limitations of MSCs and NSPCs and provides a roadmap for optimizing their clinical translation

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Unlock the future of healing with Compendium of Diseases and Disorders: Clinical Applications of Stem Cells with Precision in Regenerative Medicine. Authored by pioneering scientist Prof. Dr. Mike Chan, this groundbreaking volume bridges cutting-edge research and real-world clinical application. It explores how targeted progenitor and precursor stem cells can transform the treatment of a wide range of diseases—from neurodegenerative conditions and cardiovascular disorders to aging-related syndromes and immune deficiencies. Designed for healthcare professionals, researchers, and innovators, this compendium offers a visionary yet practical guide to the evolving frontiers of regenerative medicine, emphasizing precision, ethical responsibility, and hope for conditions once deemed untreatable.

Prof. Dr. Mike K.S. Chan is an author, educator, and pioneer in Cellular, Organo, and Cell Membrane Therapies in Europe and Asia since the early 1980s. He founded one of the world’s largest research groups in Bio-Molecular Medicine, headquartered in Switzerland and Germany, with a global presence in nearly eighty countries. He has delivered more than 1,000 lectures, seminars, and symposiums worldwide in the fields of anti-aging, cell regeneration, bio-regenerative medicine, and stem cell therapies.
He is the author or co-author of over 50 scientific and medical books covering stem cells, aging, neurodegenerative and neurodevelopmental disorders, metabolic diseases, and biological as well as regenerative medicine. Prof. Dr. Chan serves on the board and chairs the Scientific Committee for Regenerative Medicine at ESAAM. He is also an Associate Professor at AASCP, USA; an Adjunct Professor and Fellow of Lincoln University College, USA (Kuala Lumpur campus); Chairman of the Medical Association for Regenerative Medicine in Japan (MMJ – Multi-Dimensional Holistic Medical Team Japan); and a Senator of BWA, Germany (Federal Association for Economic Development and Foreign Trade), representing China, Indonesia, and Malaysia.
He has played a pivotal role in advancing medical and wellness tourism, as well as educational tourism, in Switzerland, Germany, and Malaysia collaborating with physicians from the USA, Portugal, Poland, Belgium, China, Spain, the UK, Indonesia, Taiwan, Australia, New Zealand, Thailand, Singapore, Vietnam, the Philippines, and the Middle East.

Prof. Dr. Michelle B.F. Wong is a distinguished scientist, researcher, and educator, actively engaged in stem cell research and development (R&D), with a particular focus on fetal precursor stem cell therapy. For over three decades, she has served as Co-Founder, Senior Technical Advisor, and Researcher at FCTI Inc., a company specializing in stem cell research and bio-regenerative medicine.Her solid academic foundation in nutrition and naturopathy has facilitated a seamless transition into R&D within the field of stem cell bioregenerative medicine.
Dr. Wong is also a highly respected speaker, regularly delivering presentations at educational programs and international conferences on topics such as stem cells, cell therapy, and biological medicine—benefiting physicians and healthcare practitioners worldwide.

💡 About the Publication:

This comprehensive review explores the cutting-edge advancements in stroke and brain injury management, focusing on the revolutionary integration of cellular, molecular, and regenerative therapies.

📌 Key Highlights:

✔️ Explores the complex biological mechanisms of neurodegeneration and repair
✔️ Showcases the role of stem cells, peptides, and mitochondrial therapies in promoting neuroregeneration
✔️ Highlights the latest developments in personalized medicine, neurorehabilitation, and neuroprotective strategies
✔️ Bridges neuroscience, regenerative medicine, and functional recovery—offering renewed hope for patients with neurological injuries

This publication represents the next generation of neurorepair science, merging evidence-based research with futuristic approaches to restore brain function and enhance patient quality of life.

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Authors: Prof. Dr. Mike K.S. Chan, Siti Azmah Jambo, Mohd. Iskandar Jumat, Florisa Landa, Nur Shafawati Saili, Dianah Florentius, Nuryasmin Ezzaty, Raz Haziqah Hani Razali, Brenda Song Pei Chui, Aziera Farhanah Adihidayah Suardi, Sze Huey Sang, Dr. Dmytro Klokol, Dr. Olha Nishkumai, Dr. Margarita Iemeliyanova, Dr. Yuriy Nalapko, Thomas Skutella, Jonathan R.T. Lakey and Prof. Dr. Michelle B.F. Wong
Publisher: Journal of Stem Cell Research; 6(1), 2025
Publisher's URL: https://doi.org/10.52793/JSCR.2025.6(1)-71

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With over 830 million people affected globally, metabolic syndrome and type 2 diabetes are among the fastest-growing chronic conditions of our time. This study introduces a groundbreaking, non-pharmacological prevention strategy using low-intensity neuromuscular and musculoskeletal activation exercises—tailored especially for individuals with mobility limitations.

📌 Key Findings:

✔️ Up to 20.4% reduction in post-meal blood glucose levels

✔️ Significant decrease in systolic and diastolic blood pressure

✔️ Effective activation of GLUT4 and AMPK pathways—even without insulin

✔️ Positive outcomes achieved in just 12 minutes of seated exercise

✔️ Supports cardiovascular health, metabolic balance, and anti-aging benefits

These results highlight how structured, accessible exercise routines can be a vital part of bioregenerative medicine, improving glycemic control and promoting healthy aging—especially in populations with limited access to conventional therapies.

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In a groundbreaking study, researchers are now exploring the potential of using a patient’s own bone marrow-derived stem cells to provide stem cell therapy for managing diabetes – essentially harnessing the body’s own power! 💪

Here are some key insights…

✅ A Safer Approach: Could using a patient’s own bone marrow stem cells (autologous BMMNCs) offer a potentially safer route for diabetes therapy by minimizing risks seen with donor cells?

✅Potential for Better Control: Clinical studies suggest autologous BMMNC infusion holds promise for improving blood sugar levels (HbA1c) and possibly reducing insulin needs in Type 1 & Type 2 Diabetes.

✅ Hope for Patients with Complications: This therapy shows potential for addressing difficult diabetes-related issues e.g. conditions like kidney problems (nephropathy) or non-healing foot ulcers.

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🔍 What’s Inside?
Known predominantly for its role in kidney health and anti-aging, the Klotho protein is now gaining recognition for its powerful influence on cardiovascular function.

This review explores:
✔️ The systemic role of Klotho beyond renal function
✔️ How Klotho deficiency contributes to hypertension, arterial stiffness, cardiac hypertrophy, and vascular calcification
✔️ The emerging therapeutic potential of Klotho in cardioprotection, vascular aging, and endothelial function
✔️ Links between Klotho signaling pathways and oxidative stress, inflammation, and calcium-phosphate balance

By moving beyond the kidney, this paper reframes our understanding of Klotho as a critical cardiovascular regulator—highlighting its promise in the fight against heart disease and age-related vascular decline.

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Did you know that the human brain is a complex network of billions of diverse cells? Understanding each type of cell and their function could be the key to unlocking the secrets behind brain health, aging, and neurological disorders…

Some crucial insights include:

✅ Glial cells are just as numerous and vital as neurons! They provide essential support, maintaining the brain’s environment and ensuring rapid communication.

✅ Mapping brain cells in detail is critical for developing targeted treatments for neurodegenerative diseases like Alzheimer’s and Parkinson’s.

✅ Age-related changes don’t affect the whole brain equally; areas crucial for decision-making (like the prefrontal cortex) tend to be the most severely affected.

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Peptides are shaping up to be the new trailblazers in the pursuit of unlocking longevity. Researchers in this recent study explore the role of bioactive short peptides that were derived from stem cells in influencing key biological functions 🌱

Here's why it’s important:

✅️ Restoring cellular function: By enhancing ATP production and reducing oxidative stress, these peptides support higher energy metabolism

✅️ Regulating metabolism rate: Promoting metabolic balance optimizes insulin sensitivity and enhances glucose uptake, which can potentially reduce the risk of high blood sugar levels

✅️ Boosting immunity systems: Stimulating the production of stem cell activity helps with tissue regeneration and repair, which provides strength in fending off diseases and infections

With its remarkably high potency and specificity, the study highlights the significant potential of these peptides in redefining how we promote longevity and our approach in the fight against age-related diseases!

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This textbook of trichology is a valuable resource for all students, from undergraduate to postgraduate, as well as clinicians. It is comprehensive in its coverage of hair physiology and diseases, with illustrations and pictures to make reading it an enjoyable experience. This textbook fulfils the requirements of medical students with basic science issues. At the same time, clinicians will find it an ideal companion as its content is concise and easy to refer to, while postgraduate students will thrive on its up-to-date data and facts from hair and scalp research. The clinical chapters cover all common and rare diseases in all age groups. The book incorporates various therapeutic modalities, including integrative medicine, cell therapy psychotherapy, and conventional medicine. The chapters are written in a simplified, crisp, practical, and user-friendly style, with many illustrations and classical photographs exhibiting features of selected diseases.

Interest in trichology is developing rapidly, with many doctors and aestheticians establishing exclusive trichology clinics. The volume of patients concerned with hair condition and appearance is ever-increasing. The interest and enthusiasm in this subject continue to grow substantially. Therefore, all dermatology and aesthetic medicine stakeholders must furnish and update themselves in the field of hair and hair diseases. Renowned authors with expertise in trichology have shared their knowledge and experience to make this book a success.

Prof. Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular, Organo and Cell Membrane Therapies in Europe and Asia since the early 1980’s. He founded one of the world’s largest research group of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, bio-regenerative medicine, and stemcell therapies. Author & co-author of numerous books and articles in the fields of cell therapy, immunology, bio-regenerative sciences, nutrition, and innovator of cellular based nutraceuticals & cosmeceuticals, Prof. Mike Chan is also the founder of European Wellness Biomedical Group—an International chain of research and treatment facilities (European Wellness Centers & Retreats) involved in anti-aging, longevity and education (European Wellness Academy). He chairs and also sits on board on numerous prominent antiaging and cell therapy associations of the world.

Dr. G. K. Glen Alvin is a Clinical Researcher and Dermatologist, has made significant contributions to the field. His educational journey includes pre-medicine studies, an undergraduate Medical Doctor (MD) degree, and post-graduate training in Dermatology. Dr. Alvin’s professional experience spans various roles, including House Officer and Medical Officer in Malaysia. For a decade, he served as a Dermatologist at Queen Elizabeth General Hospital in Sabah, Malaysia, and later as a Consultant Dermatologist at Jesselton Medical Centre.
His impactful research covers topics such as leprosy guidelines, melasma treatments, and novel options for enhancing eyebrows and eyelashes. Dr. Alvin also serves as a reviewer for the International Journal of Dermatology (IJD) and the Malaysian Journal of Medicine (MJM). As a member of editorial boards, he contributes to journals focused on Cell Biology, Dermatology & Dermatitis, and Dermatology Research and Reports. Additionally, he shares his expertise as a Dermatological Advisor and Speaker for pharmaceutical companies.