Publications

Autologous Antigen-Specific Immunotherapy (AASI) is redefining how we treat autoimmune and immune-mediated diseases, from Type 1 diabetes and multiple sclerosis to allergies, organ transplantation, and even cancer.

In this comprehensive new article, discover how AASI leverages a patient’s own immune cells to restore immune tolerance with precision, safety, and potential applications across diverse clinical fields.

🔬 Key Highlights:

✔️ Explains how AASI targets disease-causing antigens while preserving normal immunity
✔️ Showcases cutting-edge AASI platforms: tolerogenic dendritic cells (tolDCs), nanoparticles, peptide conjugates, and CAR-Tregs
✔️ Explores clinical potential for autoimmune diseases (T1D, MS, SLE, RA), allergies, transplant rejection, and cancer
✔️ Highlights challenges and future directions in biomarker profiling, AI-guided antigen selection, and personalized delivery systems
✔️ Emphasizes safety and selectivity as the next frontier in immune tolerance therapy

This review calls for a shift from immunosuppression to immune education toward a future of targeted, lasting, and safer interventions.

🧬 AASI isn’t just a treatment. It’s a paradigm shift in immunotherapy.

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A new scientific review just published in the American Journal of Biomedical Science & Research explores a fresh approach to managing Crohn’s Disease – by focusing on restoring immune balance and repairing gut integrity from the inside out.

Led by experts from European Wellness – including Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, and Prof. Dr. Dmytro Klokol – alongside collaborators from UC Irvine and GATC Health Inc, this review lays the foundation for a more targeted, potentially more holistic path forward in this field.

What their research helped uncover:
🔹 Advanced cell-based approaches, like organoid and stem cell therapies, may help rebuild damaged gut lining
🔹 Peptide-powered strategies may reduce inflammation, support healing, and bring precision to immune regulation
🔹 Tolerogenic immune training – an approach that could potentially teach the immune system to stop overreacting without suppressing it entirely
🔹 A combined framework that aims to go beyond symptoms by addressing root imbalances

Research is still in early stages – but the possibilities are definitely worth exploring. This research could signal a promising shift for patients living with IBD worldwide.

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💡 About the Article:

Alzheimer’s Disease (AD) is a complex neurodegenerative disorder with no known cure. This comprehensive review presents a holistic, multi-pronged strategy that goes beyond conventional treatments—integrating cutting-edge approaches from regenerative medicine, cellular therapy, and personalized lifestyle interventions.

📌 Key Highlights:

✔️ The article explores the roles of neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic failure in AD pathology
✔️ It introduces the potential of peptide therapy, nano-organo preparations, and cell therapy to modulate neurodegeneration and promote neuroregeneration
✔️ Emphasis on the gut-brain axis, blood-brain barrier integrity, and immune modulation as therapeutic targets
✔️ Advocates for an integrative care model—blending science-based interventions with functional, metabolic, and lifestyle medicine for optimal brain health and quality of life

🔬 This paper charts a forward-looking path for managing AD with precision tools that address root causes—not just symptoms—of cognitive decline.

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Authored by an international team that includes European Wellness experts Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, Prof. Dr. Dmytro Klokol and Prof. Dr. Olha Nishkumai alongside researchers from the University of California, Irvine (UCI), the study explores advanced peptide therapeutics that specifically target mitochondrial dysfunction, fibrosis, and inflammation – 3 critical factors in cardiac disease.

Here’s why this research is exciting…
🔹 Peptides can be engineered to reach specific cells and organelles in the heart, potentially reducing side effects compared to traditional treatments.
🔹 Preclinical trials show potential in repairing damaged heart tissue, reducing inflammation, and improving cardiac function.
🔹 Novel peptide systems like NOPs (nano-organo peptides) and MTPs (mitochondria-targeted peptides) may help fine-tune treatment like never before.

Research continues – but this could be a major step toward a new kind of precision therapy for one of the world’s biggest health challenges! 💡

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💡 What’s Inside?

While traditionally known for energy production, mitochondria are now recognized as master regulators of wellness—influencing everything from neurodegeneration and immune health to metabolic balance and aging.

This article explores how Mitochondrial Organelle (MO) Therapy, using peptide formulations like MF-Plus, is revolutionizing regenerative medicine by restoring mitochondrial function and reversing cellular decline.

📌 Key Highlights:

✔️ Mitochondria regulate ATP production, calcium homeostasis, redox signaling, and apoptosis prevention
✔️ MO peptides and mitochondrial-derived vesicles (MDVs) support regeneration, anti-aging, and disease recovery
✔️ Evidence of efficacy in neurodegenerative, cardiovascular, metabolic, and dermatological conditions
✔️ Routes of administration include intramuscular, intravenous, and mesotherapy, shown to support both aesthetic and clinical benefits
✔️ Potential applications in stroke recovery, ischemia, fatty liver disease, and cellular rejuvenation

🔬 This article sheds light on mitochondria’s central role in orchestrating biological repair and how mitochondrial transfer and MO-based therapies may soon become the cornerstone of precision regenerative medicine.

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💡 About the Article:
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with no FDA-approved treatments targeting its core biological mechanisms. This review explores the promising role of therapeutic peptides in modulating the underlying neurobiology of ASD.

📌 Key Highlights:

✔️ Peptides can cross the blood-brain barrier and target neuroinflammation, synaptic plasticity, and mitochondrial dysfunction
✔️ Mitochondria-derived peptides (MDPs) like Humanin, MOTS-c, and SHLP2 enhance neuronal survival, reduce oxidative stress, and modulate immune responses
✔️ Nano Organo Peptides (NOPs) and Mitochondrial Organelle (MO) Peptides represent next-gen therapies for metabolic restoration, neuroimmune modulation, and synaptic repair
✔️ Clinical studies on peptides like Oxytocin, VIP, Melatonin show early promise in improving social behaviors, sleep, and reducing neuroinflammation in ASD
✔️ Peptide therapies may bridge neurobiology with precision therapeutics, offering a path toward true disease-modifying interventions for ASD

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A cutting-edge review in the American Journal of Biomedical Science & Research explores a question that could reshape the future for millions of children: Can stem cell therapy reverse the course of Type 1 Diabetes in the pediatric population?

Authored by an international team including European Wellness founder Prof. Dato’ Sri Dr. Mike Chan and Prof. Dato’ Sri Dr. Michelle Wong, this pivotal paper examines how mesenchymal, hematopoietic, and pluripotent stem cells might not only shield β-cells from autoimmune attacks but also regenerate insulin-producing function. 🧬

Key Highlights:

✅ Immune Resetting with HSCs shows potential in stopping early-stage autoimmune destruction.

✅ MSC Therapies demonstrate glycemic control benefits with immunomodulation.

✅ iPSCs & ESCs pave the way for personalized β-cell regeneration.

✅ Pediatric Trials reveal encouraging early safety and efficacy signals.

The findings suggest stem cells could one day offer more than just ‘disease management’ for children around the world who suffer from this disease…

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Authors: Krista Casazza, Carolina Bluguermann, Ian Jenkins, Bradley Robinson, Pedro Gutierrez-Castrellon, Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Yizhen Deng, Hongjin Wu, Adrian Mutto and Jonathan R.T. Lakey
Publisher: American Journal of Biomedical Science & Research; 26(5), 2025
Publisher's URL: https://biomedgrid.com/pdf/AJBSR.MS.ID.003474.pdf

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Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Ian Jenkins and Jonathan R.T. Lakey
Publisher: American Journal of Biomedical Science & Research; 26(6), 2025
Publisher's URL: https://biomedgrid.com/pdf/AJBSR.MS.ID.003494.pdf

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Stroke is a critical medical emergency and a leading cause of disability and death worldwide. Within minutes of the stroke or interruption of the blood supply, the affected cells begin to die, potentially leading to devastating neurological consequences. This book explores the science behind stroke, its causes, mechanisms, and management, discussing the biological processes that govern cerebral circulation and mechanisms for repair and recovery potential.

The book provides an in-depth look at the biological approach to stroke management, including cellular and molecular mechanisms to understand stroke pathophysiology, from energy failure and excitotoxicity to immune responses and neurodegeneration. The manuscript comprehensively discusses the role of neuropeptides, growth factors, and other biologically active molecules that may aid in brain repair and functional recovery. It also highlights the physiotherapeutic and regenerative strategies, emphasising the importance of neurorehabilitation techniques, including physiotherapy, brain stimulation, and emerging regenerative medicine approaches to enhance recovery. Next, a post-stroke recovery and rehabilitation chapter examines strategies to maximise neurological function, including dietary interventions, physical activity, cognitive therapy, and assistive technologies.

Beyond traditional treatment, the book presents how cutting-edge therapies, including stem cell research, neuroplasticity training, and personalised medicine, transform post-stroke care. With advances in neuroscience and regenerative medicine, there is renewed hope for stroke survivors to regain lost function and improve their quality of life. This book offers an insightful and scientifically-backed resource on the biological mechanisms of stroke and the latest advancements in management and rehabilitation.

Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.

Dr Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.