Authors: Dr. Alaa Abdelkarim, Shirene Amer and Prof. Dr. Mike K.S. Chan
Publisher: Journal of Regenerative Medicine & Biology Research; 7(1), 2026
Publisher's URL: https://doi.org/10.46889/JRMBR.2026.7106
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Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662974298, eISBN: 9781662974304
Library of Congress Control Number: 2026936405
Golf may look gentle, but for millions of players it quietly delivers a heavy—and often chronic—injury toll. Golf Players’ Injuries: BioRegenerative Sport Medicine & Holistic Perspectives reframes “nagging” golf pain as a predictable outcome of repetitive, asymmetrical swing mechanics, accumulated load, and incomplete tissue recovery. From low back pain and shoulder dysfunction to golfer’s elbow, wrist tendinopathies, hip and knee problems, this book maps the most common injury patterns across amateurs and professionals—and explains why they happen.
Blending sports medicine, biomechanics, and modern healing science, the authors move beyond symptom control to explore a biology-driven approach aimed at genuine tissue restoration. You’ll discover how kinetic-chain breakdowns contribute to specific injuries, how cellular and molecular repair can stall, and what emerging regenerative tools—such as precursor stem cell concepts, exosomes, nano-peptides, mitochondrial support, and advanced physiotherapy modalities—may offer when conventional care falls short.
Written for golfers, clinicians, and performance professionals, this is a practical, evidence-informed guide to understanding golf injuries, improving diagnosis, and supporting a safer, stronger return to play.
Prof. Dato’ Sri Dr. Mike K.S. Chan is Founder & Chairman of the European Wellness Biomedical Group and Chief Researcher/Chief Technical & Research Director across its international R&D programs. A pioneer of cellular therapy since the 1980s, he helped introduce stem cell and bioregenerative medicine across Asia, building a global network of clinics and research centers—today a chain of 40+ integrative and regenerative medical clinics with 1,000+ staff. He serves as ESAAM Scientific Committee Head for Regenerative Medicine & Stem Cells and ESAAM Chairman/Director for Asia; Associate Professor (AASCP, USA); Associate Professor (Lincoln University College, Kuala Lumpur); Chairman of the European Wellness Academy; Senator of Germany’s BWA; and Honorary Chief Healthcare Advisor to Swiss Strategic Partners. His portfolio includes multiple international patents in immunotherapy, stem cell transport media, and parenteral formulations, and he is a multi-award recipient in Europe and the Middle East. An active academic collaborator (MIT, Cambridge, USC, UCI, Heidelberg), Prof. Chan has authored/co-authored 60+ books and 150+ scientific publications, and has delivered 1000+ lectures and seminars across 60+ regions on anti-aging, regenerative medicine, peptides, and stem cell therapies.
Dr. Dina Tulina is a Medical Advisor and physician specializing in anti-aging, regenerative medicine, and comprehensive wellness. She integrates preventive, biological, and natural care to promote longevity and vitality beyond conventional practice. At European Wellness Global, she contributes to biomedical innovation with holistic approaches and the translation of research into practical applications. Guided by her belief that true health is balance and vitality, and functional longevity, Dr. Tulina is dedicated to shaping the future of personalized and preventive healthcare.
Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662971044, eISBN: 9781662972843
Neuroregeneration and Novel Insights in Borderline Emotional Disorders in Regenerative Medicine explores the “clinical gray zone” where persistent stress, anxiety, low mood, and emotional dysregulation impair daily life without always fitting neat diagnostic categories. Written for clinicians, researchers, and informed readers, it reframes “borderline” states through a dimensional, mechanism-based lens—linking fluctuating symptoms to stress circuits, neuroendocrine signaling, inflammation, metabolic function, mitochondrial bioenergetics, and the gut–brain axis.
Bridging established psychiatric care with emerging biological strategies, the book surveys evidence-informed adjuncts such as neuromodulatory peptides, organoid and mito-organelle research platforms, cellular and glial-focused approaches, and structured physiotherapeutic and lifestyle interventions. Practical in intent and translational in scope, it offers a roadmap for integrating psychosocial treatment with safety-minded, biologically rational tools—aimed at enhancing resilience, restoring homeostasis, and supporting earlier, more personalized intervention before symptoms harden into chronic disorder.
Prof. Dato’ Sri Dr. Mike K.S. Chan is Founder & Chairman of the European Wellness Biomedical Group and Chief Researcher/Chief Technical & Research Director across its international R&D programs. A pioneer of cellular therapy since the 1980s, he helped introduce stem cell and bioregenerative medicine across Asia, building a global network of clinics and research centers—today a chain of 40+ integrative and regenerative medical clinics with 1,000+ staff. He serves as ESAAM Scientific Committee Head for Regenerative Medicine & Stem Cells and ESAAM Chairman/Director for Asia; Associate Professor (AASCP, USA); Associate Professor (Lincoln University College, Kuala Lumpur); Chairman of the European Wellness Academy; Senator of Germany’s BWA; and Honorary Chief Healthcare Advisor to Swiss Strategic Partners. His portfolio includes multiple international patents in immunotherapy, stem cell transport media, and parenteral formulations, and he is a multi-award recipient in Europe and the Middle East. An active academic collaborator (MIT, Cambridge, USC, UCI, Heidelberg), Prof. Chan has authored/co-authored 60+ books and 150+ scientific publications, and has delivered 1000+ lectures and seminars across 60+ regions on anti-aging, regenerative medicine, peptides, and stem cell therapies.
Dr. Dina Tulina is a Medical Advisor and physician specializing in anti-aging, regenerative medicine, and comprehensive wellness. She integrates preventive, biological, and natural care to promote longevity and vitality beyond conventional practice. At European Wellness Global, she contributes to biomedical innovation with holistic approaches and the translation of research into practical applications. Guided by her belief that true health is balance and vitality, and functional longevity, Dr. Tulina is dedicated to shaping the future of personalized and preventive healthcare.
European Wellness researchers and collaborators have published a compelling new review in the American Journal of Biomedical Science & Research – exploring how mitochondrial dysfunction sits at the very heart of metabolic syndrome, and how targeted peptide therapies could help restore the body's metabolic engine from the inside out!
💡 Why this matters:
- Metabolic syndrome is one of the defining health challenges of our time, and conventional approaches often target symptoms one organ at a time.
- Rather than addressing isolated symptoms, this research points toward a holistic, hypothesis-driven model that targets the root cause - cellular energy failure.
- While more clinical trials are needed, the science points toward an exciting future where peptide-based therapies could help restore the body's natural metabolic flexibility and reduce cardiometabolic risk at its source.
- The paper explores two promising frontiers in peptide-based intervention: Mitochondrial-derived peptides and Multi-organ peptide constructs.
Targeting Mitochondrial Bioenergetic Failure in Metabolic Syndrome: Translational Roles of Mitochondrial and Multi-Organ Peptides
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza and Jonathan R.T. Lakey
American Journal of Biomedical Science & Research; 30(4), 2026
https://biomedgrid.com/pdf/AJBSR.MS.ID.003933.pdf
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Authors: Dr. Roni Lara Moya, Dr. Dmytro Klokol, Prof. Dr. Michelle B.F. Wong and Prof. Dr. Mike K.S. Chan
Publisher: Journal of Stem Cell Research; 7(2), 2026
Publisher's URL: TBA
will be available on 4 April 2026
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What if metabolic syndrome isn't really about blood sugar and belly fat – but a total communication breakdown inside your cells? 🧬
European Wellness researchers have just published a compelling new review in Neurology – Research & Surgery – exploring how metabolic syndrome may actually be a systems-wide collapse of peptide signaling across your organs, and how regenerative peptide biology could offer a new way to address it at the source!
Here's the big picture:
- The paper reframes Metabolic Syndrome as a coordinated collapse of peptide-governed networks connecting the gut, pancreas, liver, muscles, fat tissue, and mitochondria.
- When these communication lines break down, things such as insulin sensitivity, inflammation, and cellular energy production start falling out of sync.
- This review explores how next-gen peptide therapeutics may help reconnect the network, including Mitochondrial Peptides, Nano Organo-Peptides, Klotho Peptides, Organ-Specific Peptides, and Mito Organelles.
Metabolic syndrome affects nearly 1 in 4 adults worldwide – and conventional treatments often manage symptoms without addressing the deeper biological failures driving the condition.
This review positions regenerative peptide therapeutics as a coherent, systems-level strategy capable of restoring the upstream peptide networks that keep our metabolism balanced, resilient, and healthy.
Metabolic Syndrome as a Multisystem Network Disorder: Therapeutic Potential of Regenerative Peptide Biology
by
Prof. Dr. Mike K.S. Chan, Krista Casazza, Prof. Dr. Michelle B.F. Wong, Dr. Dmytro Klokol and Jonathan R.T. Lakey
📅 Published: February 07, 2026
Neurology – Research & Surgery; 9(1), 2026
https://www.scivisionpub.com/journals/neurology-research-surgery/articles/metabolic-syndrome-as-a-multisystem-network-disorder-therapeutic-potential-of-regenerative-peptide-biology
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About the Article:
Erectile dysfunction (ED) is a common male health condition with complex multifactorial causes, including vascular, neurological, endocrine, and psychosocial contributors. Traditional therapies like phosphodiesterase type 5 inhibitors remain first‑line, but they don’t fully address underlying tissue, nerve, or metabolic dysfunction.
This review presents a comprehensive management framework that blends conventional diagnostics and pharmacotherapy with emerging regenerative and integrative strategies, targeting the biological roots of ED and expanding therapeutic possibilities beyond symptom control.
Key Themes Covered:
✔️ Detailed overview of ED pathophysiology and clinical assessment
✔️ Conventional medical treatments and personalized management principles
✔️ Regenerative medicine approaches, including cell‑based and peptide‑based therapeutics
✔️ Lifestyle, metabolic, and psychosocial considerations in ED care
✔️ A future‑forward framework integrating traditional care with regenerative innovation
By uniting established evidence and next‑generation therapeutic concepts, this article highlights a holistic path forward for improving erectile function and overall male sexual health.
Modern Management of Erectile Dysfunction: An Integrative and Regenerative Therapeutic Framework
by
Dr. Dmytro Klokol, Prof. Dr. Michelle B.F. Wong, Dr. Volodymyr Chernykh, Dr. Margaryta Yemeliyanova, Dr. Olha Nishkumay, Dr. Glen Alvin and Prof. Dr. Mike K.S. Chan
SSP Modern Pharmacy & Medicine; 6(1), 2026
https://doi.org/10.53933/7z0cx674
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Authors: Prof. Dr. Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Dr. Olha Nishkumai and Dr. Dmytro Klokol
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662971921, eISBN: 9781662971938
Peptides 101: Regenerative Applications in Modern Medicine provides a foundational overview of peptide biology and their expanding therapeutic roles in regenerative and functional medicine. The book reviews peptide structure, synthesis, and signaling pathways, with emphasis on their applications in tissue repair, immune modulation, neuroprotection, and metabolic regulation. Integrating current research with clinical perspectives, it highlights safety profiles, evidence-based protocols, and emerging trends in peptide therapeutics. Designed for clinicians, biomedical researchers, and students, this text bridges basic science and translational medicine to illuminate the regenerative potential of peptide-based interventions.
Unlock the therapeutic power of peptides—nature’s own precision messengers—in this comprehensive introduction to their role in regenerative and integrative medicine. From cellular signaling and tissue repair to neuroprotection and metabolic optimization, Peptides 101 demystifies complex biochemical pathways and translates cutting-edge science into practical medical insight.
Inside, you’ll explore:
- Core principles of peptide biology and receptor signaling; Clinical applications in reversal of chronic diseases and metabolic syndrome, wound healing, longevity and neuroregeneration;
- Evidence-based discussion of safety, dosing, and protocols;
- Future directions in peptide-based therapeutics and personalized medicine.
- Whether you’re a physician, researcher, or student of modern bioregenerative science, this book provides the foundation and framework to understand and apply peptide therapy responsibly and effectively.
Prof. Dato’ Sri Dr. Mike K.S. Chan, Researcher, Author, and Educator, Founder and Chairman of the European Wellness Biomedical Group; Senior Technical Consultant at EWBG; Head of Scientific committee of preventive, regenerative and anti-aging medicine and Asian Chairman (ESAAM); Adjunct Professor of Lincoln University College (Malaysia); Associate Professor of AASCP, USA (American Academy of Stem Cell Physicians), Chairman for A4M, USA (American Academy of Anti-Aging Medicine) for Thailand/Asia, Japan’s Regenerative Medical Association MMJ (Multi-Dimensional Holistic Medical Team Japan) and co-Founder of FCTI Precursor Stem Cells (Europe), Author of over 70 books and over 150 publications, has experience of 45 over years in Stem cells Research in Germany, Switzerland, European Union, Soviets, China, Mexico, USA, Japan, Middle East since early 80’s, presenter for over 10000 presentations and scientific lectures globally at most major conferences of the World on anti-aging and precision medicine. He is also a pioneer in Regenerative Medicine and Cellular Therapies in a big way in the 80’s into Asia Pacific, the Middle East and Australia.
Thomas Skutella, MD, PostDoc (Max Planck Institute for Psychiatry, Munich, Germany), Full Professor at Heidelberg University, former group leader in the Neuroscience Research Center (Charite Berlin, Germany), director of the Center for Regenerative Medicine (Tübingen, Germany), Head of the department of Neuroanatomy in the Institute for Anatomy and Cell Biology (Heidelberg, Germany), Group for Regeneration and Reprogramming, Medical Faculty, Institute for Anatomy and Cell Biology, Heidelberg University (Germany).
Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D. (University of Alberta at Edmonton, Canada), Professor Emeritus, Department of Surgery, University of California Irvine (CA, USA); Department of Biomedical Engineering, University of California Irvine (CA, USA), Director of Research at the Clinical Islet Program in the Department of Surgery at the University of California, Irvine (CA, USA), Outstanding Leadership in Alberta Science Award from the Alberta Science and Technology Leadership Foundation, the Outstanding Achievement Award from the Canadian Diabetes Association, and Royal College of Physicians and Surgeons.
Olha Nishkumai, MD, PhD, Professor, Doctor of Medical Sciences, Board Certified Specialist Cardiologist, Rheumatologist, and Internal Medicine specialist; Full Professor at the Department of Internal Medicine No. 2 at Bogomolets National Medical University (UA); Medical Consultant at the European Wellness Biomedical Group.
Dmytro Klokol, MD, Specialist in General Surgery (Board Certified, MoH UA), PhD (Emergency and Reconstructive Surgery), GCP (Malaysia, USA), PostDoc (Regenerative Medicine, NL, EU); Certified expert in Interventional procedures in Regenerative Medicine and chronic pain management (Spain, EU); Certified Educator at International Accreditation Organization (IAO, USA); HRDCorp certified educator and trainer (Malaysia); International Board for Anti-aging and Regenerative Medicine (IBARM, USA) certifying academic board member.
European Wellness researchers and collaborators have just published an important new study in SSP Modern Pharmacy and Medicine – revealing a hidden link between kidney stone disease and bone health that standard bone density tests might miss!
Here's What It's About:
✅ The research team studied 80 patients to understand how kidney stone disease (nephrolithiasis) affects fracture risk
✅ Standard bone mineral density (BMD) tests showed no difference between patients with and without kidney stones
✅ However, the Trabecular Bone Score (TBS) – which measures bone quality and microarchitecture – was significantly lower in kidney stone patients
✅ When TBS was factored into the 10-year fracture risk calculation, patients with kidney stones showed a notably higher risk of fractures
This means traditional bone density scans alone may not tell the full story for people with kidney stone disease.
💡 Why This Matters:
Kidney disease can disrupt vitamin D metabolism and trigger secondary hyperparathyroidism – a double threat that affects both stone formation and bone integrity. By incorporating TBS into fracture risk assessments, clinicians can identify at-risk patients earlier and begin preventive therapy sooner – potentially avoiding life-altering fractures down the road.
Assessment of the Fractures Risk in Patients with Nephrolithiasis
by
Oleg Nikitin, Illia Kordubailo, Dr. Olha Nishkumay. Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Dr. Dmytro Klokol, Oksana Zaytseva and Hennadii Reznikov
SSP Modern Pharmacy & Medicine; 5(4), 2025
https://doi.org/10.53933/0waq5n36
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Here's What It's About:
This case report follows a 27-year-old patient with severe corneal opacity treated over 90 days using ACE Retino (sublingual and topical peptides) and Cataclear (bioactive eye drops).
Key observations include:
- 92% improvement in corneal clarity
- Significant visual acuity gains
- Reduced stromal edema
- And marked improvements in inflammatory and oxidative biomarkers – all without surgical intervention.
💡 Why This Matters:
Corneal opacity affects millions globally and often requires surgery with associated risks. This preliminary case suggests peptide-based therapies targeting inflammation, oxidative stress, and fibrosis may offer a promising non-invasive alternative – though larger controlled trials are needed.
Efficacy of ACE Retino and Cataclear in Treating Adult Corneal Opacity
by
Mohamed Yasser Sayed Saif, Alaa Abdelkarim Mohamed Fouad, Shireen SalahEldin Amer, Winfred Amoako, Prof. Dr. Mike K.S. Chan, Ahmed Tamer Sayed Saif and Passant Sayed Saif
Research Square; 2025
https://doi.org/10.21203/rs.3.rs-6683358/v1
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Authors: Prof. Dr. Mike K.S. Chan and Dr. Simon Yefimov
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662963834, eISBN: 9781662963841
Proactive Ageing: Comprehensive Strategies for Muscle Preservation and Sarcopenia Resistance is an essential guide which reveals the hidden epidemic of sarcopenia, the silent muscle-wasting condition that affects millions as they age. With a deep dive into the root causes—hormonal imbalances, chronic inflammation, and lifestyle choices—this book arms you with the knowledge to detect and prevent muscle loss before it takes its toll.
Readers will explore the cutting-edge world of regenerative medicine which offers breakthrough therapies like peptide treatments and mitochondria-specific interventions offer new hope for reversing muscle decline. Whether you’re a healthcare professional or someone determined to stay strong and active as the years go by, this book offers a comprehensive, science-backed roadmap to maintaining muscle health, preventing age-related diseases, and living a vibrant, long life.
Prof. Dato’ Sri Dr. Mike K.S. Chan is Founder & Chairman of the European Wellness Biomedical Group and Chief Researcher/Chief Technical & Research Director across its international R&D programs. A pioneer of cellular therapy since the 1980s, he helped introduce stem cell and bioregenerative medicine across Asia, building a global network of clinics and research centers—today a chain of 40+ integrative and regenerative medical clinics with 1,000+ staff. He serves as ESAAM Scientific Committee Head for Regenerative Medicine & Stem Cells and ESAAM Chairman/Director for Asia; Associate Professor (AASCP, USA); Associate Professor (Lincoln University College, Kuala Lumpur); Chairman of the European Wellness Academy; Senator of Germany’s BWA; and Honorary Chief Healthcare Advisor to Swiss Strategic Partners. His portfolio includes multiple international patents in immunotherapy, stem cell transport media, and parenteral formulations, and he is a multi-award recipient in Europe and the Middle East. An active academic collaborator (MIT, Cambridge, USC, UCI, Heidelberg), Prof. Chan has authored/co-authored 60+ books and 140+ scientific publications, and has delivered 1000+ lectures and seminars across 60+ regions on anti-aging, regenerative medicine, peptides, and stem cell therapies..
Dr. Simon Yefimov MD earned his medical degree from Luhansk State Medical University (2006–2012). During his academic journey, he was an active member of the Academic Community Mental Health and received recognition for his contributions. Notably, he won a prize at the Mental Health national academic competition in 2010. His qualifications include a radiology specialist degree from Luhansk State Hospital (2012–2014) and a radiological investigations medical specialist degree (2013–2014). Dr. Yefimov further honed his skills through practical courses, including ultrasound research at Luhansk Regional Oncologic Dispensary and contrast-enhanced radiological studies at Luhansk State Hospital. Professionally, Dr. Yefimov served as a radiologist at Luhansk Municipal Hospital Number 4 (2014–2015) before joining the Diagnostic and Treatment Centre “Meddiagnostika” in Kiev, where he continues to practice as a radiologist. Additionally, he has been actively involved in Cell Therapy, Biological, Integrative & Regenerative Medicine in Europe since 2016. Dr. Yefimov’s research interests led him to co-author an article titled “CELL THERAPY AS THE MAIN STRATAGEM OF ANTI-AGING AND REGENERATIVE MEDICINE,” published in the European Journal of Pharmaceutical And Medical Research (2019, 6(6), 295–299). His technical expertise encompasses fixed radiography systems (both digital and analog), mobile x-ray systems, and ultrasound systems.
European Wellness researchers and collaborators have just published a comprehensive review in the Journal of Neurological Sciences and Research – exploring how tinnitus is now understood as a complex brain network disorder, and how peptide-based regenerative therapies may offer a promising new path forward!
Here's the breakthrough:
Tinnitus affects 10 – 15% of adults globally – yet current treatments only manage symptoms. This paper digs into the real culprits:
✅ Cochlear injury sparking maladaptive brain rewiring
✅ Oxidative stress, mitochondrial dysfunction, and neuroinflammation keeping the "phantom sound" alive
✅ Limbic–auditory network disruptions fueling emotional distress
The potential solution?
Peptide-based biologics – including Mito-Organelles (MO), Nano Organo-Peptides (NOP), and Precursor Stem Cell–derived factors – that can:
✅ Restore cellular energy and calm hyperactive neurons
✅ Rebalance brain circuits and reduce aberrant neural "noise"
✅ Support neuro-regeneration at the source
Tinnitus and the Brain: Neurobiological Mechanisms and the Emerging Role of Peptide-Based Regenerative Therapy
by
Prof. Dr. Mike K.S. Chan, Krista Casazza, Prof. Dr. Michelle B.F. Wong, Dr. Dmytro Klokol and Jonathan R.T. Lakey
Journal of Neurological Sciences and Research; 5(2), 2025
http://doi.org/10.52793/JNSR.2025.5(2)-48
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Authors: Prof. Dr. Mike K.S. Chan, Dr. Olha Nishkumai, Dr. Dmytro Klokol, Dr. Simon Yefimov, Dr. Nataliia Shyshkina, Dr. Halyna Mostbauer, Dr. Marta Dzhus, Dr. Tatiana Karasevska and Dr. Nataliia Grygorieva
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9786176321309
Osteoarthritis (OA), once viewed as an inevitable consequence of aging and joint “wear and tear,” is now being redefined by rapid advances in our understanding of inflammation, cartilage biology, and regenerative medicine. OA is no longer merely a condition to be managed with symptom relief — it is becoming a target for true biological intervention.
Our book presents a comprehensive and timely exploration of the evolving landscape in OA treatment. This book brings together the best of two worlds: evidence-based conventional medicine and the emerging promise of bioregenerative and cellular therapies.
In these pages, readers will find an in-depth analysis of the multifactorial nature of osteoarthritis — from metabolic and mechanical contributors to molecular and immunologic underpinnings. The chapters traverse the full spectrum of interventions, including pharmacologic management, physical rehabilitation, nutraceuticals, targeted biologicals, and cutting-edge cell-based approaches such as stem cell therapy and tissue engineering.
This integrative approach reflects a necessary paradigm shift. The complexity of OA requires more than a one-size-fits-all solution. By combining the wisdom of established clinical practice with the in-novation of regenerative strategies, this volume charts a path toward not just pain control, but true joint preservation and restoration.
As researchers, physicians, and patients continue to seek treatments that go beyond masking symptoms to addressing root causes, regenerating joints serves as both a guide and a call to action. It invites clinicians to expand their therapeutic arsenal and researchers to push the boundaries of what is possible in joint regeneration.
May this book inspire collaboration, curiosity, and continued progress in our shared goal: restoring mobility, function, and quality of life for those affected by osteoarthritis.
About the Article:
Reproductive health is critical to the welfare, performance, and sustainability of animal populations, from companion animals to livestock and equines. Traditional reproductive management strategies often focus on hormonal modulation or assisted reproductive technologies, which can improve breeding efficiency but may not address the underlying cellular, endocrine, and metabolic dysfunctions that contribute to infertility and sub‑fertility in animals.
This comprehensive review synthesizes the latest evidence on peptide‑based therapies and organ‑derived biologics as next‑generation tools in animal reproductive care. Peptide therapeutics, whether synthetic, stem‑cell secretome‑derived, or organ extract‑based offer targeted modulation of:
- Endocrine balance and steroidogenesis
- Mitochondrial bioenergetics and oxidative homeostasis
- Angiogenesis and tissue repair by modulating key reproductive and regenerative pathways
Peptide Therapy in Animal Reproductive Health: Advances, Mechanisms, and Translational Perspectives
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol and Jonathan R.T. Lakey
Journal of Stem Cell Research; 7(1), 2025
https://doi.org/10.52793/JSCR.2026.7(1)-80
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About the Article:
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers worldwide, with survival rates below 10% and few effective treatment options. Claudin 18.2 (CLDN18.2) has emerged as a promising tumor‑specific target for immunotherapy.
This article reports on engineered VHH‑based CAR‑T cells, using a single‑domain antibody (VHH) as the antigen‑binding domain that demonstrate potent anti‑tumor activity against CLDN18.2‑expressing pancreatic cancer in preclinical models. These next‑generation constructs show strong cytokine responses and sustained cytotoxicity, highlighting their potential to overcome limitations of traditional scFv‑based CAR‑T designs.
Unlike traditional CAR-T constructs, these VHH-based versions, utilizing single-domain antibodies, offer enhanced stability, reduced immunogenicity, and potent cytotoxic activity. The results show:
- Sustained cytokine release
- Effective tumor eradication in vitro and in vivo
- Promising safety and specificity profiles
This study adds to the growing body of work demonstrating the potential of next-generation CAR-T cell therapies for solid tumors like pancreatic cancer.
VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models
by
Ying Xing, Gangqiang Shi, Zhengli Li, Xiancheng Liu, Yu Zhang, Yiqin Song, Shilin Sun, Yuping Chen, Xuekai Zhu, Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Thomas Skutella, Krista Casazza, Jonathan R.T. Lakey and Yunfeng Feng
Frontiers in Immunology; T Cell Biology (16), 2025
https://doi.org/10.3389/fimmu.2025.1638585
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About the Article:
Chronic Kidney Disease (CKD) is a progressive condition marked by nephron loss, fibrosis, inflammation, and impaired renal function. This review explores the Pico Cell Matrix of ACE Reno, a bioactive regenerative matrix derived from kidney, placental, atrial tissues, and mesenchymal stem cells (MSCs) and its potential to halt and reverse CKD pathology in an adenine‑induced animal model.
Key Themes Include:
- Organ‑specific regenerative potential: Pico Cell Matrix delivers peptides and signaling molecules that support nephron regeneration, organ repair, and anti‑fibrotic activity.
- Improved kidney structure and function: Treated kidneys showed restored glomerular architecture, enhanced podocyte integrity, and increased capillary density.
- Molecular mechanisms: ACE Reno modulated key pathways, suppressing TGF‑β and epithelial–mesenchymal transition, promoting mitochondrial repair via PGC‑1α, supporting angiogenesis (VEGF‑A/Ang1), and rebalancing antifibrotic and anti‑inflammatory signals such as miR‑29.
- Potential paradigm shift: These findings position ACE Reno’s Pico Cell Matrix as a promising organ‑specific, cell‑free regenerative intervention that goes beyond conventional palliative care.
Pico Cell Matrix of ACE Reno and its effect on Adenine induced chronic Kidney disease
by
Mohamed Yasser Sayed Saif, Sohair Fahmi, Alaa Abdelkarim, Shireen Salaheldin Amer and Prof. Dr. Mike K.S. Chan
NILES Journal for Geriatric and Gerontology; 8(4), 2025
https://doi.org/10.21608/niles.2025.393926.1123
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Authors: Prof. Dr. Mike K.S. Chan, Leigh Steinberg and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662970504, eISBN: 9781662970511
Concussion – The Hidden Trauma in contact Sports and the NFL - Concussion and mild traumatic brain injury (mTBI) represent a spectrum of neurological injuries that have gained unprecedented attention in recent decades, particularly within the realm of sports medicine. The recognition and understanding of concussion symptoms have evolved dramatically, driven largely by high-profile cases in professional sports, especially the National Football League (NFL), and mounting scientific evidence about the serious nature of these seemingly "mild" injuries.
The symptomatology of concussion is complex and multifaceted, encompassing physical, cognitive, emotional, and sleep-related manifestations that can vary significantly between individuals and across different contexts. In sports settings, particularly in contact sports like American football, the presentation and recognition of these symptoms carry unique challenges and implications that extend far beyond the playing field.
This book provides a comprehensive examination of concussion symptoms, with particular emphasis on sports-related concussion and the landmark developments in understanding that have emerged from NFL research, policy changes and holistic approach of its management. The evolution of symptom recognition in professional football has not only transformed how we approach sports-related brain injury but has also influenced broader medical understanding of mild traumatic brain injury across all populations.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Leigh Steinberg is a legendary sports agent, entrepreneur, and Chairman of Steinberg Sports and Entertainment, widely known as the real-life inspiration for Jerry Maguire. He has represented over 300 professional athletes—including 64 NFL first-round picks, 8 number one overall selections, and 12 Hall of Famers—and has negotiated contracts exceeding $4 billion while directing over $1.2 billion to charitable causes. A UC Berkeley graduate, Leigh is also a philanthropist, media personality, and author. He recently established The Leigh Steinberg Foundation for Concussion, Traumatic Brain Injury, and Brain Health to continue championing brain health and making a lasting difference in athletes’ lives.
Dr. Dina Tulina is a Medical Advisor and physician specializing in anti-aging, regenerative medicine, and comprehensive wellness. She integrates preventive, biological, and natural care to promote longevity and vitality beyond conventional practice. At European Wellness Global, she contributes to biomedical innovation with holistic approaches and the translation of research into practical applications. Guided by her belief that true health is balance and vitality, and functional longevity, Dr. Tulina is dedicated to shaping the future of personalized and preventive healthcare.
Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662965289, eISBN: 9781662965296
Library of Congress Control Number: 2025940634
Holistic Advances for Parkinson’s Disease: The Comprehensive Management with Biological Approach, Personalized Cellular Perspectives, Mitochondrial, and Neural Peptides Benefits offers an integrative and forward-thinking perspective on the management of Parkinson’s disease (PD), uniting decades of scientific discovery with emerging biological therapies. This book delves deep into the multifactorial nature of PD, presenting a personalized roadmap that includes cellular regenerative strategies, mitochondrial support, and the therapeutic potential of neural and bioactive peptides.
Written for clinicians, researchers, and informed patients, it explores innovative pathways that go beyond symptom control—addressing the root biological dysfunctions that drive disease progression. From cellular modulation and neuroplasticity enhancement to autonomic balance and mitochondrial optimization, this book offers a truly comprehensive and holistic vision for improving outcomes and restoring quality of life in those affected by Parkinson’s Disease.
Holistic Advances for Parkinson’s Disease is a transformative resource for anyone seeking to understand and implement the next generation of Parkinson’s care.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy “He, who owns the youth, owns the future”, Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.
Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Yuriy Nalapko and Dr. Svetlana Yartseva
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9781662968549, eISBN: 9781662968556
Library of Congress Control Number: 2025947548
Diabetes: Bioregenerative Medicine with Stem Cell Therapy is a comprehensive book covering the basic scientific facts about the metabolic disorders. It contains the modern concepts of the occurrence, development, and course of obesity, metabolic syndrome, and its complications, e.g., type 2 diabetes mellitus and cardiovascular disorders. Grounded in the recent findings of clinical and laboratory studies, the authors reveal the principal causes of the complications of the metabolic disorders and propose structural approaches to the treatment and prevention of its progression.
Featuring modern concepts of the treatment of obese, diabetic and metabolic syndrome patients, the book includes interventions such as lifestyle changes, dietary approaches, evidence-based pharmacology, and bioregenerative medicine. Demonstrating the weak links in the pathogenesis of these metabolic disorders and their complications, the authors present the scientifically proven recommendations for preventive and restorative measures. Combining deep science with current practice, this book contains easy-to-use recommendations regarding diet, physical activities, medicinal options, and bioregenerative potential to cure metabolic disorders. Narrow and deep review as well as the authors combined medical and research experience will be of value to persons with diabetes and metabolic syndrome, their physicians, and all who has interest in regenerative and antiaging medicine.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of cellular and cell membrane therapy in Europe and Asia since the early 1980s. He founded one of the world’s largest researchers of bio-molecular medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Yuriy Nalapko, MD, PhD, is an academician and practical medical doctor in intensive care, antiaging, and bioregenerative medicine—an area of scientific interest in longevity and how a cell functions with different diseases. He is the author of many handbooks, monographs, and more than 300 articles. Based on his clinical experience, he proposed new approaches to reverse degenerative diseases of the brain, liver, and endocrine organs in different disorders. In metabolic disorder therapy, he combines preventive, pharmacological, and bioregenerative approaches as a state-of-the-art paradigm to correct structural and functional malfunctions.
Dr. Svetlana Yartseva, MD, PhD, is a certified endocrinologist and internal diseases practitioner. A member of several international associations on the study of diabetes, such as the European Thyroid Association and the European Association of Preventive, Regenerative, and Antiaging Medicine, she is a consultant at numerous private clinics. Her main concern is treatment of patients with obesity, metabolic syndrome, and diabetes mellitus through modern pharmacological and non-pharmacological methods.
Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9781662964947, eISBN: 9781662964954
Library of Congress Control Number: 2025939690
Sleep is a fundamental biological function essential for physical and mental well-being. It is critical in memory consolidation, tissue repair, immune system regulation, and metabolic balance, contributing to an increased risk of cardiovascular disease, obesity, diabetes, neurodegenerative disorders and premature ageing. Sleep disorders—especially insomnia—affect millions worldwide, leading to profound consequences on daily life and long-term health. Insomnia, characterised by difficulty falling asleep, staying asleep, or waking too early, is more than an inconvenience. Modern lifestyles have exacerbated sleep problems, with artificial light exposure, increased screen time, and 24-hour work cycles disrupting natural circadian rhythms. These factors, combined with psychological stress, anxiety, and poor sleep hygiene, have led to an epidemic of sleep disturbances. Social jetlag—where biological clocks are misaligned with modern schedules—is particularly common in adolescents and professionals, worsening insomnia and leading to long-term health consequences. The book explores how technology, societal pressures, and environmental influences have reshaped sleep patterns and how individuals can restore balance through targeted interventions.
This book presents an integrative approach, combining evidence-based lifestyle modifications, cognitive-behavioral therapies, and biological interventions to offer sustainable solutions for sleep improvement. One of the key focuses of this book is the intersection of sleep science with regenerative medicine. Cutting-edge research highlights the role of cellular repair, neuroprotection, and overall vitality. The book also discusses the latest advancements in sleep-enhancing therapies, including nutraceuticals, peptide treatments, and biohacking strategies aimed at improving sleep architecture and circadian alignment.
By exploring the science behind insomnia and offering practical, integrative solutions, this book serves as a valuable resource for anyone seeking to improve their sleep quality and overall health. Whether you are a healthcare professional, researcher, or someone struggling with sleep disturbances, you will find the tools and insights to reclaim restorative sleep and enhance longevity in this book.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.

























