Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9781662964947, eISBN: 9781662964954
Library of Congress Control Number: 2025939690
Sleep is a fundamental biological function essential for physical and mental well-being. It is critical in memory consolidation, tissue repair, immune system regulation, and metabolic balance, contributing to an increased risk of cardiovascular disease, obesity, diabetes, neurodegenerative disorders and premature ageing. Sleep disorders—especially insomnia—affect millions worldwide, leading to profound consequences on daily life and long-term health. Insomnia, characterised by difficulty falling asleep, staying asleep, or waking too early, is more than an inconvenience. Modern lifestyles have exacerbated sleep problems, with artificial light exposure, increased screen time, and 24-hour work cycles disrupting natural circadian rhythms. These factors, combined with psychological stress, anxiety, and poor sleep hygiene, have led to an epidemic of sleep disturbances. Social jetlag—where biological clocks are misaligned with modern schedules—is particularly common in adolescents and professionals, worsening insomnia and leading to long-term health consequences. The book explores how technology, societal pressures, and environmental influences have reshaped sleep patterns and how individuals can restore balance through targeted interventions.
This book presents an integrative approach, combining evidence-based lifestyle modifications, cognitive-behavioral therapies, and biological interventions to offer sustainable solutions for sleep improvement. One of the key focuses of this book is the intersection of sleep science with regenerative medicine. Cutting-edge research highlights the role of cellular repair, neuroprotection, and overall vitality. The book also discusses the latest advancements in sleep-enhancing therapies, including nutraceuticals, peptide treatments, and biohacking strategies aimed at improving sleep architecture and circadian alignment.
By exploring the science behind insomnia and offering practical, integrative solutions, this book serves as a valuable resource for anyone seeking to improve their sleep quality and overall health. Whether you are a healthcare professional, researcher, or someone struggling with sleep disturbances, you will find the tools and insights to reclaim restorative sleep and enhance longevity in this book.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.
Here’s what it’s about:
The research team connects three powerful fronts of regenerative medicine – and shows how they can work together rather than in silos:
✅ Stem cells act as the ‘repair engine’ – helping to rebuild damaged tissues and reduce inflammation
✅ Mitochondrial peptides are the ‘resilience signal’ – boosting cell energy and healing
✅ Nanomized peptides are the ‘precision carrier’ – enhancing stability and bioavailability to reach the right site at the right time
Combined, they could help in the treatment of joint issues, age-related diseases, and even organ damage – all with potentially better precision and faster recovery! The paper also discusses practical considerations (safety, dosing, standardisations) to help veterinarians translate this amazing technology into everyday practic.
💡 Why this matters:
Our pets are living longer and staying active – and that brings a surge of age-related and degenerative conditions to consider. This integrated strategy aims to deliver faster recovery, stronger function, and more quality years to our adorable friends, pairing cellular repair with metabolic support and precision delivery.
Next-Generation Regenerative Therapies in Companion Animals: Integrating Stem Cells, Mitochondrial Peptides, and Nanomized Peptides for Targeted Tissue Repair
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol and Jonathan R.T. Lakey
American Journal of Biomedical Science & Research; 28(4), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003697.pdf
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This authoritative work explores how mitochondrial peptides, cell extracts, and mito organelle-based therapies are reshaping regenerative medicine and anti‑aging science. The book dives into their mechanisms, therapeutic implications, and strategies for harnessing mitochondrial health to promote longevity and functional vitality.
Key Themes Include:
- How mitochondrial dysfunction contributes to aging and disease
- Mito peptides and organelle extracts: their modes of action in restoring cellular energy, reducing oxidative stress, and promoting repair
- Preclinical and early clinical evidence for using cell extracts and mito-based interventions to address age‑related decline
- Practical considerations: delivery methods, dosing, formulation, safety, and combinational strategies
- Lifestyle, supplement, and regenerative adjuncts to support mitochondrial resilience
Why This Studies Matter:
For anyone interested in longevity, wellness, anti‑aging therapies, or regenerative medicine, this is your go‑to resource. It bridges cutting‑edge molecular biology with practical applications for boosting cellular function, combating aging, and enhancing overall healthspan.
Mitochondrial Peptides and Cell Extracts in Regenerative Medicine and Anti‑Aging Therapies: Therapeutic Potential of Mito Organelles
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Dr. Volodymyr Chernykh, Dr. Margaryta Yemeliyanova, Dr. Glen Alvin, Dr. Olha Nishkumai, Dr. Nataliia Shyshkina, Jonathan R.T. Lakey and Thomas Skutella
Journal of Stem Cell Research; 6(2), 2025
https://doi.org/10.52793/JSCR.2025.6(2)-78
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In this pivotal research, the authors explore how key calcification markers like Osteopontin (OPN), Osteocalcin (OC), and FGF23 interact with salt metabolism and kidney stone formation — while also connecting these mechanisms to bone mineral density and aging.
Here’s what the study found:
- People with kidney stones or crystalluria had much higher levels of three key substances in their bodies: FGF23, osteocalcin (OC), and osteopontin (OPN) – all of which are linked to bone loss and blood vessel calcification.
- One of those, FGF23, stood out. High levels of FGF23 were strongly linked to phosphate levels in the blood. This makes it a potentially powerful early warning sign of kidney damage.
- Even when standard kidney tests looked normal, these markers told a different story – showing signs of hidden kidney stress and mineral imbalances that could speed up aging or lead to other chronic conditions.
- The researchers also suggest that too much phosphate in the diet may be making things worse – putting more pressure on the kidneys and increasing the risk of kidney stones and bone problems.
💡 Why does this matter?
Because it shows how deeply connected your kidneys, bones, blood vessels, and aging processes really are – and why early testing and proper nutrition could help prevent major health issues later in life!
Analysis of salt transport indices, calcification markers, and FGF23 in patients with nephrolithiasis and crystalluria
by
Oleh Nikitin, Ilya Kordubailo, Dr. Olha Nishkumay, Prof. Dr. Mike K.S. Chan and Dr. Dmytro Klokol
KIDNEYS; 14(3), 2025
https://doi.org/10.22141/2307-1257.14.3.2025.545
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Authors: Prof. Dr. Mike K.S. Chan and Dr. Dmytro Klokol
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9786176321286
Inside these pages, you’ll discover:
- Clinically documented remarkable improvements in neurodevelopmental disorders, recoveries from liver and kidney failure, stroke, Parkinson’s, heart failure, and beyond.
- Emerging protocols combining stem cells with bioactive molecules and exosomes — protocols shaping tomorrow’s care.
- Practical insights into safety, delivery routes, and outcome metrics.
- A critical view on current limitations, future potential, and medical responsibility.
- Pathways to healing: clinical strategies and cellular intelligence - from stem cell origins to measurable recovery in real-world medicine.
Stem Cells: The Untold invites you to look beyond the headlines—and into the evidence-based exploration of stem cell therapeutics as they transition from investigational to clinical application. From hypothesis to healing—this book captures the translational arc of stem cell medicine in contemporary practice.
Not merely a sequel to Stem Cells in Regenerative Medicine: Carpe Diem, Carpe Vitam!, but a new genesis — Stem Cells: The Untold captures the extraordinary clinical evolution and scientific breakthroughs that have redefined regenerative medicine in less than a decade.
Prof. Dr. Dmytro Klokol MD, PhD
Anti-aging and regenerative medicine and surgery expert. Head of Medical Advisory, European Wellness Biomedical Group — Main author and editor-in-chief.
Prof. Dr. Mike K.S. Chan
Founder & Chairman of the European Wellness Biomedical Group, Head of Scientific Commitee for Regenerative Medicine & Asian Chairman — ESAAM (European Society of Preventive, Regenerative & Anti-Aging Medicine).
This evidence-based publication dives deep into how specific anabolic and regenerative peptides can support body recomposition, helping you build muscle, reduce fat, accelerate recovery, and push performance, all while understanding safe and effective usage.
Key Highlights:
✔️ Mechanisms of Action — how peptides work at the cellular level (muscle hypertrophy, fat metabolism, tissue repair)
✔️ Dosing Strategies — evidence-based guidance on dosing, timing, delivery, and cycles
✔️ Comparative Review — what peptides show the strongest data vs. those still emerging
✔️ Safety Profiles — risks, side effects, and ethical & legal considerations
✔️ Real-world applications for bodybuilders, athletes, and anyone interested in performance + composition enhancement
Emerging Anabolic and Regenerative Peptides in Athletic Body Re-composition and Bodybuilding: Mechanisms of Action, Dosing Strategies, and Evidence Review
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Dr. Volodymyr Chernykh, Dr. Margaryta Yemeliyanova, Dr. Glen Alvin, Dr. Olha Nishkumai, Jonathan R.T. Lakey and Dr. Dmytro Klokol
Journal of Stem Cell Research; 6(2), 2025
https://www.genesispub.org/emerging-anabolic-and-regenerative-peptides-in-athletic-body-re-composition-and-bodybuilding-mechanisms-of-action-dosing-strategies-and-evidence-review
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Authors: Prof. Dr. Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Dr. Dmytro Klokol, Florisa Landa, Nur Shafawati Saili, Siti Azmah Jambo, Brenda Song Pei Chui, Raz Haziqah Hani Razali, Max Michael Samson, Aziera Farhanah Adihidayah Suardi, Fiona Macniesia Thomas, Chin Mei Ling, Krista Casazza, Isso Kimura, Mohd Iskandar Jumat and Prof. Dr. Michelle B.F. Wong
Publisher: Advances in Clinical and Medical Research; 6(2), 2025
Publisher's URL: https://www.genesispub.org/mapping-human-organ-aging-from-cellular-mechanism-to-clinical-applications-for-precision-medicine-in-healthspan-to-lifespan
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Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9781662964961, eISBN: 9781662964978
Neurodegenerative diseases, particularly Alzheimer’s disease and dementia, are among the most significant medical and societal challenges of the twenty-first century. The progressive loss of cognitive functions, including memory, thinking, language, and decision-making characterizes these conditions. As the ageing population continues to grow, the prevalence of these disorders is increasing rapidly, making them a primary focus of research, healthcare, and public awareness.
Neurodegenerative Diseases - Alzheimer’s Disease and Dementia provides an in-depth exploration of Alzheimer’s disease and various forms of dementia, emphasizing the biological mechanisms that drive these conditions. One of the book’s primary focuses is the current and emerging treatments for Alzheimer’s disease and dementia. Although no cure exists, researchers have developed various pharmacological and non-pharmacological strategies to manage symptoms and improve patients’ quality of life. The book examines innovative approaches which can enhance cognitive function and emotional well-being. It also emphasizes the importance of caregiver support, stress management, and different resources to assist families in providing compassionate care.
Beyond traditional treatments, the book explores groundbreaking advancements in neurodegenerative disease research. It discusses the potential of cellular approaches, gene editing, and neuroprotective drugs, as well as the role of artificial intelligence in early diagnosis and personalized treatment plans. Readers will gain insights into the future of neuroscience in combating Alzheimer’s and other dementias. By combining up-to-date scientific knowledge with practical strategies, this book aims to empower patients, caregivers, and healthcare professionals in the fight against neurodegenerative diseases. Early detection, lifestyle modifications, and ongoing research are crucial in enhancing the quality of life for those affected.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.
Authors: Prof. Dr. Mike K.S. Chan and Dr. Dina Tulina
Published by: EUROPEAN WELLNESS ACADEMY
Medical Research: ISBN: 9781662964817, eISBN: 9781662964824
Memory is a fundamental cognitive function that enables individuals to absorb, retain, and utilize information acquired through experience. It shapes knowledge, skills, and abilities, interacting dynamically with individuals’ mental and personal attributes. This bidirectional relationship means that while memory depends on accumulated experiences and learning, it also contributes to their continuous development. Cognitive impairment, often called an intellectual or learning disability, includes limitations in mental processing, social interactions, communication, and self-sufficiency.
This book explores the intricate nature of memory and its role in overall cognitive health and potential interventions for memory decline. The discussion extends beyond conventional medical approaches, including integrative and innovative solutions that bridge traditional wisdom with modern scientific advancements.
Enhancing Memory: Integrative Approaches with Innovative Solutions to BrainSpan in Longevity & Regenerative Medicine focuses on a holistic approach to memory enhancement, combining neuroscience, regenerative medicine, and alternative therapies. The book integrates time-tested traditional remedies with cutting-edge biological research, providing a comprehensive perspective on improving and maintaining memory function. Including original biological products further underscores the synergy between scientific progress and practical applications in cognitive health management. Whether dealing with mild memory lapses, seeking preventive measures, or managing more complex neurological conditions, readers will find practical and evidence-based guidance to support brain longevity and overall mental well-being.
Ultimately, this book serves as both an educational resource and a practical guide for anyone interested in understanding the science behind memory preservation and cognitive enhancement. It emphasizes that with early detection, proactive intervention, and continuous research, individuals can take meaningful steps toward maintaining cognitive vitality throughout life.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr Dina Tulina is a specialist in anti-aging and regenerative medicine with extensive experience in the field. Basing her knowledge on scientific and research experience within the scope of neuropsychiatry (age-related brain changes and associated cognitive and mental disorders), Dr Dina has expanded and enriched her expertise by incorporating preventative medicine, natural and complementary therapies for age-related changes, and the use of biologics in regenerative medicine. Guided by the philosophy "He, who owns the youth, owns the future", Dr Dina is deeply passionate about the educational aspects of anti-aging medicine and wellness.
Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Waldemar Lernhardt, Eric Mathur, Dr. Dmytro Klokol, Ian Jenkins and Jonathan R.T. Lakey
Publisher: American Journal of Biomedical Science & Research; 28(2), 2025
Publisher's URL: https://biomedgrid.com/pdf/AJBSR.MS.ID.003664.pdf
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Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Yuriy Nalapko and Dr. Svetlana Yartseva
Published by: EUROPEAN WELLNESS ACADEMY
Obesity and Metabolic Syndrome: Bioregenerative Medicine with Stem Cell Therapy is a comprehensive book covering the basic scientific facts about the metabolic disorders. It contains the modern concepts of the occurrence, development, and course of obesity, metabolic syndrome, and its complications, e.g., type 2 diabetes mellitus and cardiovascular disorders. Grounded in the recent findings of clinical and laboratory studies, the authors reveal the principal causes of the complications of the metabolic disorders and propose structural approaches to the treatment and prevention of its progression.
Featuring modern concepts of the treatment of obese, diabetic and metabolic syndrome patients, the book includes interventions such as lifestyle changes, dietary approaches, evidence-based pharmacology, and bioregenerative medicine. Demonstrating the weak links in the pathogenesis of these metabolic disorders and their complications, the authors present the scientifically proven recommendations for preventive and restorative measures. Combining deep science with current practice, this book contains easy-to-use recommendations regarding diet, physical activities, medicinal options, and bioregenerative potential to cure metabolic disorders. Narrow and deep review as well as the authors combined medical and research experience will be of value to persons with diabetes and metabolic syndrome, their physicians, and all who has interest in regenerative and antiaging medicine.
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of cellular and cell membrane therapy in Europe and Asia since the early 1980s. He founded one of the world’s largest researchers of bio-molecular medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
Dr. Yuriy Nalapko, MD, PhD, is an academician and practical medical doctor in intensive care, antiaging, and bioregenerative medicine—an area of scientific interest in longevity and how a cell functions with different diseases. He is the author of many handbooks, monographs, and more than 300 articles. Based on his clinical experience, he proposed new approaches to reverse degenerative diseases of the brain, liver, and endocrine organs in different disorders. In metabolic disorder therapy, he combines preventive, pharmacological, and bioregenerative approaches as a state-of-the-art paradigm to correct structural and functional malfunctions.
Dr. Svetlana Yartseva, MD, PhD, is a certified endocrinologist and internal diseases practitioner. A member of several international associations on the study of diabetes, such as the European Thyroid Association and the European Association of Preventive, Regenerative, and Antiaging Medicine, she is a consultant at numerous private clinics. Her main concern is treatment of patients with obesity, metabolic syndrome, and diabetes mellitus through modern pharmacological and non-pharmacological methods.
Led by European Wellness scientists Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, and Prof. Dr. Dmytro Klokol, in collaboration with top researchers from UC Irvine and GATC Health, this groundbreaking paper presents powerful new insights into how peptide therapeutics could potentially halt – and even reverse – vision loss caused by RP.
What this research reveals:
🔹 RP isn’t just genetic – inflammation, oxidative stress, and immune dysfunction accelerate degeneration.
🔹 Bioactive peptides (like thymosin β4 and KPV) can potentially retrain the immune system and promote retinal repair.
🔹 A breakthrough technique called Antigen Adaptive Selective Immunotherapy (AASI) may potentially stop immune attacks on retinal cells – restoring immune balance without suppressing the whole immune system.
🔹 Next-gen delivery systems are enhancing peptide stability, precision, and efficacy – offering new hope for long-term visual preservation.
This is a huge leap forward in the race to help patients affected by RP – and it opens the door to similar strategies for other neurodegenerative eye diseases. A game-changer in the making!
Recalibrating Retinal Immunity: Peptide-Based Strategies for Durable Vision Preservation in Retinitis Pigmentosa
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Waldemar Lernhardt, Dr. Dmytro Klokol, Ian Jenkins and Jonathan R.T. Lakey
📅 Published: August 11, 2025
American Journal of Biomedical Science & Research; 28(1), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003638.pdf
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Autologous Antigen-Specific Immunotherapy (AASI) is redefining how we treat autoimmune and immune-mediated diseases, from Type 1 diabetes and multiple sclerosis to allergies, organ transplantation, and even cancer.
In this comprehensive new article, discover how AASI leverages a patient’s own immune cells to restore immune tolerance with precision, safety, and potential applications across diverse clinical fields.
🔬 Key Highlights:
✔️ Explains how AASI targets disease-causing antigens while preserving normal immunity
✔️ Showcases cutting-edge AASI platforms: tolerogenic dendritic cells (tolDCs), nanoparticles, peptide conjugates, and CAR-Tregs
✔️ Explores clinical potential for autoimmune diseases (T1D, MS, SLE, RA), allergies, transplant rejection, and cancer
✔️ Highlights challenges and future directions in biomarker profiling, AI-guided antigen selection, and personalized delivery systems
✔️ Emphasizes safety and selectivity as the next frontier in immune tolerance therapy
This review calls for a shift from immunosuppression to immune education toward a future of targeted, lasting, and safer interventions.
🧬 AASI isn’t just a treatment. It’s a paradigm shift in immunotherapy.
Autologous Antigen-Specific Immunotherapy (AASI) Precision Immune Re-education in Autoimmunity and Beyond
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol, Waldemar Lernhardt, Ian Jenkins and Jonathan R.T. Lakey
📅 Published: July 29, 2025
American Journal of Biomedical Science & Research; 27(6), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003623.pdf
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🧬 New Publication Alert!
We are proud to announce the release of our latest peer-reviewed review article in the American Journal of Biomedical Science & Research:
Immunologic Reset and Regenerative Repair: A Precision Medicine Framework for Post-Treatment Lyme Disease
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol and Jonathan R.T. Lakey
📅 Published: July 15, 2025
American Journal of Biomedical Science & Research; 27(4), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003606.pdf
💡 Why This Matters:
Post-Treatment Lyme Disease Syndrome (PTLDS) affects nearly 1 in 5 Lyme disease patients with persistent fatigue, cognitive dysfunction, pain, and autonomic disturbances—despite antibiotic therapy. This breakthrough review offers an integrative, regenerative medicine model that redefines treatment possibilities.
🔬 Key Takeaways:
✔️ Highlights the immunological roots of PTLDS: molecular mimicry, immune dysregulation, and persistent inflammation
✔️ Proposes a precision-based triad of care:
1️⃣ Organ- and tissue-specific regenerative repair (e.g. using MSCs, neural progenitors, exosomes)
2️⃣ Neuroimmune modulation to enhance cognitive and autonomic recovery
3️⃣ Antigen-Adaptive Selective Immunotherapy (AASI) to reset immune tolerance to Borrelia and self-antigens
✔️ Synthesizes emerging clinical and preclinical evidence on stem cell and exosome-based therapies
✔️ Builds a holistic framework for immune recalibration, tissue healing, and lasting recovery
This publication paves the way for a personalized, systems medicine approach to one of the most elusive chronic infectious syndromes today.
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A new scientific review just published in the American Journal of Biomedical Science & Research explores a fresh approach to managing Crohn’s Disease – by focusing on restoring immune balance and repairing gut integrity from the inside out.
Led by experts from European Wellness – including Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, and Prof. Dr. Dmytro Klokol – alongside collaborators from UC Irvine and GATC Health Inc, this review lays the foundation for a more targeted, potentially more holistic path forward in this field.
What their research helped uncover:
🔹 Advanced cell-based approaches, like organoid and stem cell therapies, may help rebuild damaged gut lining
🔹 Peptide-powered strategies may reduce inflammation, support healing, and bring precision to immune regulation
🔹 Tolerogenic immune training – an approach that could potentially teach the immune system to stop overreacting without suppressing it entirely
🔹 A combined framework that aims to go beyond symptoms by addressing root imbalances
Research is still in early stages – but the possibilities are definitely worth exploring. This research could signal a promising shift for patients living with IBD worldwide.
Restoring Immune Balance and Intestinal Integrity in Crohn’s Disease: A Framework for Targeted Regenerative and Immunomodulatory Therapies
by
Prof. Dr. Mike K.S. Chan, Ian Jenkins, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol and Jonathan R.T. Lakey
American Journal of Biomedical Science & Research; 27(4), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003587.pdf
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Authors: Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Dr. Shing Yi Pan, Dr. Volodymyr Chernykh, Dr. Nataliia Shyshkina, Dr. Margaryta Yemeliyanova, Dr. Dmytro Klokol, Dr. Olha Nishkumai, Dr. Glen Alvin, Oleg Kobzev, Svitlana Dubynska and Jonathan Lakey
Publisher: SSP Modern Pharmacy and Medicine; 5(3), 2025
Publisher's URL: https://doi.org/10.53933/61x4gw93
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💡 About the Article:
Alzheimer’s Disease (AD) is a complex neurodegenerative disorder with no known cure. This comprehensive review presents a holistic, multi-pronged strategy that goes beyond conventional treatments—integrating cutting-edge approaches from regenerative medicine, cellular therapy, and personalized lifestyle interventions.
📌 Key Highlights:
✔️ The article explores the roles of neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic failure in AD pathology
✔️ It introduces the potential of peptide therapy, nano-organo preparations, and cell therapy to modulate neurodegeneration and promote neuroregeneration
✔️ Emphasis on the gut-brain axis, blood-brain barrier integrity, and immune modulation as therapeutic targets
✔️ Advocates for an integrative care model—blending science-based interventions with functional, metabolic, and lifestyle medicine for optimal brain health and quality of life
🔬 This paper charts a forward-looking path for managing AD with precision tools that address root causes—not just symptoms—of cognitive decline.
Alzheimer’s Disease: Innovative Approaches and Emerging Strategies in Holistic Management
by
Prof. Dr. Mike K.S. Chan, Jonathan R.T. Lakey and Thomas Skutella
Advances in Clinical and Medical Research; 6(1), 2025
https://doi.org/10.52793/ACMR.2025.6(1)-96
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Authors: Dr. Dmytro Klokol, Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Dr. Volodymyr Chernykh, Dr. Margaryta Iemelianova and Dr. Glen Alvin
Publisher: Journal of Stem Cell Research; 6(2), 2025
Publisher's URL: https://doi.org/10.52793/JSCR.2025.6(2)-74
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Authored by an international team that includes European Wellness experts Prof. Dato’ Sri Dr. Mike Chan, Prof. Dato’ Sri Dr. Michelle Wong, Prof. Dr. Dmytro Klokol and Prof. Dr. Olha Nishkumai alongside researchers from the University of California, Irvine (UCI), the study explores advanced peptide therapeutics that specifically target mitochondrial dysfunction, fibrosis, and inflammation – 3 critical factors in cardiac disease.
Here’s why this research is exciting…
🔹 Peptides can be engineered to reach specific cells and organelles in the heart, potentially reducing side effects compared to traditional treatments.
🔹 Preclinical trials show potential in repairing damaged heart tissue, reducing inflammation, and improving cardiac function.
🔹 Novel peptide systems like NOPs (nano-organo peptides) and MTPs (mitochondria-targeted peptides) may help fine-tune treatment like never before.
Research continues – but this could be a major step toward a new kind of precision therapy for one of the world’s biggest health challenges! 💡
Peptide-Based Precision Therapeutics for Cardiac Disease: Targeting Mitochondrial Dysfunction, Fibrosis, and Inflammation
by
Prof. Dr. Mike K.S. Chan, Prof. Dr. Michelle B.F. Wong, Krista Casazza, Dr. Dmytro Klokol, Dr. Olha Nishkumai, Michael Alexander and Jonathan R.T. Lakey
American Journal of Biomedical Science & Research; 27(3), 2025
https://biomedgrid.com/pdf/AJBSR.MS.ID.003560.pdf
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A groundbreaking review article in Molecular Biology Reports maps out why the α-Klotho protein is fast becoming a keystone molecule for both healthy longevity and oncology! Co-authored by European Wellness founder Prof. Dato’ Sri Dr. Mike Chan along with an international team of researchers, the study reveals how Klotho might hold the key to aging and conditions such as cancer.
What makes Klotho so special?
- It acts like a control switch for major cell pathways – including Wnt, IGF-1, PI3K/AKT, and TGF-β – helping to prevent runaway cell growth and tissue damage.
- It has strong antioxidant and anti-inflammatory powers, which protect our DNA and slow down age-related wear and tear.
- In many cancers (like breast, liver, and T-cell cancers), Klotho levels are observed to drop. Restoring it may potentially hold the key to addressing cancer growth and spread.
- Researchers are developing cutting-edge ways to bring Klotho back – including gene therapy, peptides, and smart nanoparticles.
Klotho protein: a multifaceted regulator in aging and cancer dynamics
by
Sibin Nambidi, Sneha Pallatt, Antara Banerjee, Surajit Pathak and Prof. Dr. Mike K.S. Chan
Molecular Biology Reports; 52(507), 2025
https://doi.org/10.1007/s11033-025-10575-3
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