Authors: Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Olha Nishkumai and Dmytro Klokol
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662971921, eISBN: 9781662971938
Authors: Mike K.S. Chan, Thomas Skutella, Jonathan R.T. Lakey, Olha Nishkumai and Dmytro Klokol
Published by: EUROPEAN WELLNESS ACADEMY – Medical Research
Medical Research: ISBN: 9781662971921, eISBN: 9781662971938
English
Peptides 101: Regenerative Applications in Modern Medicine provides a foundational overview of peptide biology and their expanding therapeutic roles in regenerative and functional medicine. The book reviews peptide structure, synthesis, and signaling pathways, with emphasis on their applications in tissue repair, immune modulation, neuroprotection, and metabolic regulation. Integrating current research with clinical perspectives, it highlights safety profiles, evidence-based protocols, and emerging trends in peptide therapeutics. Designed for clinicians, biomedical researchers, and students, this text bridges basic science and translational medicine to illuminate the regenerative potential of peptide-based interventions.
Unlock the therapeutic power of peptides—nature’s own precision messengers—in this comprehensive introduction to their role in regenerative and integrative medicine. From cellular signaling and tissue repair to neuroprotection and metabolic optimization, Peptides 101 demystifies complex biochemical pathways and translates cutting-edge science into practical medical insight.
Inside, you’ll explore:
| LIST OF ABBREVIATIONS | X111 |
| ABOUT THE AUTHORS | XXVII |
| INSTEAD OF PROLOGUE: THE MOLECULES OF RETURN | 1 |
| CHAPTER 1 THE MOLECULAR RENAISSANCE: PEPTIDES AS PIONEERS IN REGENERATIVE MEDICINE | 7 |
| From Molecular Fragments to Therapeutic Frontiers | 7 |
| Peptides: The Forgotten Molecules Reborn | 8 |
| Mechanisms of Action: Beyond Signaling | 9 |
| Nanomization: A Paradigm Shift in Peptide Stability and Bioavailability | 14 |
| Xenogeneic and Organo-Specific Peptides: Rewriting the Source Code | 16 |
| Mitochondria-Targeted Peptides: A New Axis in Regenerative Therapeutics | 17 |
| Senescence, Inflammation, and the Aging Microenvironment | 18 |
| From Bench to Bedside: Preclinical and Translational Evidence | 24 |
| Toward a Peptide-Based Regenerative Paradigm | 25 |
| Organelle-Specific Peptides: Mitochondria as Master Regulators of Regeneration | 26 |
| Clinical Outlook of MO Peptide Therapy | 29 |
| Integration with Other Regenerative Modalities | 32 |
| Reimagining Regeneration Through Peptides | 35 |
| CHAPTER 2 THE HISTORY OF PEPTIDE THERAPY: FROM INSULIN TO ORGAN‑SPECIFIC BIOACTIVE FORMULATIONS | 39 |
| Prologue: A Century of Peptide Vision | 39 |
| The Dawn: Insulin and the Peptide Revolution | 40 |
| Organ Extracts and the Swiss/German Tradition of Tissue Therapy | 45 |
| Paul Niehans and the Era of Live Cell Therapy | 45 |
| Thymus Peptides: From Immune Modulation to Regenerative Application | 49 |
| Peptide Chemistry, Technology, and the Expansion Era | 51 |
| Mitochondrial Peptides: From Hidden Genomic Messages to Therapeutic Agents | 52 |
| The Rise of Nano‑Organic Xenogeneic Peptides | 53 |
| Interpreting the Arc: Patterns, Lessons, and Legacy | 57 |
| Epilogue: From Legacy to Frontiers | 58 |
| CHAPTER 3 SAFETY, CARCINOGENICITY, AND CHARACTERIZATION OF THERAPEUTIC PEPTIDES (with Prof. Thomas Skutella, MD, PostDoc) | 59 |
| Why Safety Matters in Peptide Therapeutics | 59 |
| MTT and Cell Transformation Assays of Mito Organelles Extracts | 60 |
| Molecular Fingerprinting and Quality Control | 66 |
| Conclusion: Confidence Through Rigor, Humility Before Complexity | 72 |
| CHAPTER 4 PEPTIDES IN CARDIOLOGY: MITOCHONDRIAL, NANO‑PEPTIDE, AND ORGAN‑SPECIFIC STRATEGIES (with Prof. Dr. Olha Nishkumai, MD, PhD) | 75 |
| Introduction: The Heart’s Peptide Frontier | 75 |
| Mitochondria in the Heart: Vulnerabilities and Therapeutic Windows | 76 |
| Nano‑Peptides, Organ-Specific Delivery and Mito Organelles in Cardiology | 80 |
| Organ-Specific Peptide Strategies and Mito Organelles | 81 |
| Case Studies and Emerging Evidence in Peptide‑Based Cardiac and Vascular Protection | 83 |
| Challenges, Unanswered Questions, and Future Directions in Cardiovascular Peptide Therapy | 86 |
| Conclusion | 87 |
| CHAPTER 5 PEPTIDES AS REGULATORS IN THE PATHOPHYSIOLOGY AND TREATMENT OF METABOLIC SYNDROME (with Prof. Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D) | 89 |
| The Peptide Network Underlying Metabolic Homeostasis | 90 |
| Mitochondrial Dysfunction and the Emergence of Mitochondrial Peptides | 93 |
| Aging, Klotho, and the Peptidic Interface of Metabolism | 95 |
| Nanomized Organ-Specific Peptides (NOPs) and Peptide Delivery Principles | 96 |
| Incretin Peptides, Dual/Triple Agonists, and Peptide Synergy | 97 |
| Peptide modulation of metabolic pathways: Mechanisms in Metabolic Syndrome | 99 |
| Clinical Indications, Patient Selection, and Therapeutic Goals | 104 |
| Protocols for Mitochondrial Peptides | 106 |
| Protocols for Klotho-Derived Peptide Fragments | 110 |
| Protocols for Nanomized Organ-Specific Peptides (NOPs) and Mito Organelles (MOs) Organ-specific Peptides (OSPs) | 111 |
| Protocols for GLP‑1 / Incretin / Multi-agonist Peptides in Metabolic Syndrome | 112 |
| Combining GLP‑1 Agonists with Mitochondrial or Klotho Peptide Therapy | 113 |
| Conclusion | 116 |
| CHAPTER 6 PEPTIDE THERAPEUTICS FOR RETINA AND OPTIC NERVE—MODULATING IMMUNITY, REGENERATION & NEUROPROTECTION | 119 |
| Pathobiology of Retinal Degeneration and Optic Neuropathy—the Rationale for Peptide Interventions | 120 |
| Bioactive Peptides in the Retina—Mechanisms of Action | 122 |
| Integration with Stem/Progenitor Cell Therapies in Glaucoma | 126 |
| CHAPTER 7 PEPTIDES IN NEURODEGENERATIVE DISORDERS— REGENERATION, PLASTICITY, AND DISEASE MODIFICATION | 131 |
| The Landscape of Neurodegeneration: Common Pathways and Therapeutic Niches | 132 |
| Parkinson’s and Synucleinopathies: Targeting α‑Synuclein with Peptides | 135 |
| Peptide-Based Treatment Protocols: Clinical Approaches with Mito Organelles and Regenerative Peptides | 139 |
| Application of Mito Organelles Peptide Therapy in Stroke Recovery | 143 |
| CHAPTER 8 PEPTIDES AS THERAPEUTIC MODALITIES IN GASTROINTESTINAL DISORDERS | 149 |
| Pathophysiology: Leaky Gut, Crohn’s Disease, and Colitis | 151 |
| Proposed Peptide Protocols and Expected Outcomes | 158 |
| CHAPTER 9 PEPTIDE-BASED STRATEGIES FOR CARTILAGE REGENERATION IN OSTEOARTHRITIS: MITOCHONDRIAL THERAPEUTICS AND MITO ORGANELLES INTEGRATION (with Prof. Jonathan R.T. Lakey, B.Sc., M.Sc., Ph.D.) | 163 |
| Mitochondrial Dysfunction in Cartilage Degeneration | 165 |
| Mito Organelles Cartilage and Placenta: A Novel Bioactive Paradigm | 170 |
| Other Peptide Therapeutics in Cartilage Restoration | 170 |
| CHAPTER 10 THYMIC PEPTIDES AND THYMUS EXTRACTS IN REGENERATIVE AND PEPTIDE-BASED MEDICINE (with Prof. Thomas Skutella, MD, PostDoc) | 175 |
| Historical Foundations and Scientific Rationale | 175 |
| Mechanisms of Action and Immunological Implications | 176 |
| Mitochondrial Thymic Peptides: Origin and Function | 180 |
| Regenerative and Anti-Aging Medicine: Immunosenescence and Thymic Rejuvenation | 185 |
| Clinical Protocols in Thymic Peptide Therapy | 187 |
| CHAPTER 11 PEPTIDES IN AESTHETIC DERMATOLOGY | 195 |
| Skin aging, dermal matrix degradation and the theoretical basis for peptides | 197 |
| Injectable peptide therapies and mesotherapy in aesthetic dermatology | 200 |
| Restoration of eyelashes and eyebrows in aesthetic dermatology | 213 |
| CHAPTER 12 HUMAN GROWTH HORMONE: DISCOVERY, SYNTHESIS, PHYSIOLOGY, AND CLINICAL APPLICATIONS IN REGENERATIVE MEDICINE (with Dr. Dmytro Klokol, MD, PhD) | 221 |
| Historical Discovery and Biotechnological Synthesis | 221 |
| Physiology: Regulation, Receptor, and Mechanism of Action | 222 |
| Mechanisms Relevant to Regenerative Medicine and Anti-Aging | 223 |
| Evidence and Clinical Applications | 224 |
| Risks, Adverse Effects, and Limitations | 225 |
| Evidence-Based Medical Data: What Is Well Established, What Is Tentative | 226 |
| Practical & Ethical Considerations and Future Directions | 226 |
| Human Growth Hormone in Anti‑Aging & Regenerative Medicine: Clinical Trials & Peptide‑Therapy Protocols | 227 |
| Clinical / Peptide Therapy Protocols: GH, GH Secretagogues, Combination Approaches | 229 |
| THE LAST CHAPTER OF THIS BOOK: PEPTIDES IN BODY BUILDING AND ATHLETIC BODY RECOMPOSITION (by Dr. Dmytro Klokol, MD, PhD) | 237 |
| Mechanisms of Action: Understanding What Peptides Do | 238 |
| Key Peptides: Anabolic, Regenerative, and Lipolytic Agents | 240 |
| Phased Use of Peptides in Bodybuilding | 241 |
| Side Effects and Risk Management | 245 |
| Insulin Use in Bodybuilding—Mechanisms, Applications, and Scientific Basis | 245 |
| Personal Perspective: Peptides at the Frontlines of Performance, Recovery, and Reinvention | 249 |
| REFERENCES | 253 |
