Beyond the Kidney-Klotho and the Cardiovascular System

🔍 What’s Inside?
Known predominantly for its role in kidney health and anti-aging, the Klotho protein is now gaining recognition for its powerful influence on cardiovascular function.

This review explores:
✔️ The systemic role of Klotho beyond renal function
✔️ How Klotho deficiency contributes to hypertension, arterial stiffness, cardiac hypertrophy, and vascular calcification
✔️ The emerging therapeutic potential of Klotho in cardioprotection, vascular aging, and endothelial function
✔️ Links between Klotho signaling pathways and oxidative stress, inflammation, and calcium-phosphate balance

By moving beyond the kidney, this paper reframes our understanding of Klotho as a critical cardiovascular regulator—highlighting its promise in the fight against heart disease and age-related vascular decline.

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