Endocrine Regulation of Kidney Disease Outcomes

New Scientific Publication Released

We are pleased to share our latest review exploring one of the most critical endocrine pathways in kidney health and disease:

Klotho and FGF23: Endocrine Regulation of Kidney Disease Outcomes

By Dr. Olha Nishkumay, Prof. Dr. Mike K.S. Chan, O.B. Iaremenko, V.E. Kondratiuk, I.V. Rudenko, O.E. Zaytseva, O.I. Rokyta and G.M. Mykytenko

About the Article:

The Klotho–FGF23 axis plays a central role in regulating mineral metabolism through the intricate interaction between the kidneys, bones, and parathyroid glands. Disruption of this pathway is now recognised as a key driver in the progression of chronic kidney disease (CKD) and its systemic complications.

This review highlights how imbalance in this endocrine system contributes to:

✔️ Phosphate and vitamin D dysregulation

✔️ Vascular calcification and accelerated ageing processes

✔️ Renal fibrosis and progressive kidney damage

✔️ Increased cardiovascular risk

Importantly, the study also underscores the protective role of Klotho, which exhibits anti-inflammatory, antioxidant, and cytoprotective effects, positioning it as both a biomarker and a promising therapeutic target in kidney disease.

Why It Matters:

Emerging evidence suggests that restoring Klotho levels may offer reno-protective and cardio-protective benefits, opening new possibilities for early diagnosis and targeted treatment strategies in nephrology.

Read more here:
https://european-wellness.eu/publications/klotho-and-fgf23/